Gamma tubulin complex component C-terminal

Definition

This is the C-terminal domain found in components of the gamma-tubulin complex proteins (GCPs). Family members include spindle pole body (SBP) components such as Spc97 and Spc98 which function as the microtubule-organizing center in yeast PMID:11134079. Furthermore, family members such as human GCP4 (Gamma-tubulin complex component 4) have been structurally elucidated [swissprot:Q9UGJ1] . Structure-based sequence analysis revealed the existence of an exposed surface area conserved in all human GCPs and in GCP4 orthologs. This area is located in the C-terminal domain of GCP4, which was confirmed in vitro to bind directly to gamma-tubulin. Sequence alignment of human GCPs based on the GCP4 structure helped delineate conserved regions in the N- and C-terminal domains PMID:21725292.

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• TUBGCP2
• TUBGCP3
• TUBGCP4
• TUBGCP5
• TUBGCP6