Seroatlas · Human Serome Atlas

ZNF417

Zinc finger protein 417

Also known as: MGC34079, ZN417_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TAU3
Gene: ZNF417
Ensembl: ENSG00000173480
Chromosome: 19
Canonical length: 575 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

575 residues, UniProt reviewed canonical sequence.

>Q8TAU3|ZNF417
     1  MAAAAPRRPT QQGTVTFEDV AVNFSQEEWC LLSEAQRCLY RDVMLENLAL ISSLGCWCGS
    61  KDEEAPCKQR ISVQRESQSR TPRAGVSPKK AHPCEMCGLI LEDVFHFADH QETHHKQKLN
   121  RSGACGKNLD DTAYLHQHQK QHIGEKFYRK SVREASFVKK RKLRVSQEPF VFREFGKDVL
   181  PSSGLCQEAA AVEKTDSETM HGPPFQEGKT NYSCGKRTKA FSTKHSVIPH QKLFTRDGCY
   241  VCSDCGKSFS RYVSFSNHQR DHTAKGPYDC GECGKSYSRK SSLIQHQRVH TGKTAYPCEE
   301  CGKSFSQKGS LISHQRVHTG ERPYECREYG KSFGQKGNLI QHQQGHTGER AYHCGECGKS
   361  FRQKFCFINH QRVHTGERPY KCGECGKSFG QKGNLVQHQR GHTGERPYEC KECGKSFRYR
   421  SHLTEHQRLH TGERPYNCRE CGKLFNRKYH LLVHERVHTG ERPYACEVCG KLFGNKNCVT
   481  IHQRIHTGER PYECNECGKS FLSSSALHVH KRVHSGQKPY KCSECGKSFA ECSSLIKHRR
   541  IHTGERPYEC TKCGKTFQRS STLLHHQSSH RRKAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF417 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 46 nTPM

Expression across tissuesHPA

Tissue

epididymis: 46 nTPM
skin: 27 nTPM
retina: 24 nTPM
tonsil: 21 nTPM
thymus: 20 nTPM
breast: 20 nTPM

Single-cell type

epididymal principal cells: 4.1 nCPM
breast myoepithelial cells: 0.9 nCPM
granulosa cells: 0.8 nCPM
retinal amacrine cells: 0.7 nCPM
salivary myoepithelial cells: 0.6 nCPM
epididymal basal cells: 0.5 nCPM

Immune cell

basophil: 5.9 nTPM
eosinophil: 5.1 nTPM
naive CD4 T-cell: 4 nTPM
naive B-cell: 3.6 nTPM
MAIT T-cell: 3.3 nTPM
neutrophil: 3.3 nTPM

Brain region

cerebellum: 59 nTPM
white matter: 52 nTPM
hypothalamus: 50 nTPM
cerebral cortex: 48 nTPM
choroid plexus: 48 nTPM
thalamus: 46 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.85
gnomAD pLI: 0.01
gnomAD missense Z: -0.3
DepMap mean gene effect: -0.24
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF417 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF417 as an antibody target. Whether an autoantibody or antibody against ZNF417 could matter depends on whether native ZNF417 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF417 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF417 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...