Seroatlas · Human Serome Atlas

MCM10

Protein MCM10 homolog

Also known as: CNA43, DNA43, MCM10_HUMAN, PRO2249

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7L590
Gene: MCM10
Ensembl: ENSG00000065328
Chromosome: 10
Canonical length: 875 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

875 residues, UniProt reviewed canonical sequence.

>Q7L590|MCM10
     1  MDEEEDNLSL LTALLEENES ALDCNSEENN FLTRENGEPD AFDELFDADG DGESYTEEAD
    61  DGETGETRDE KENLATLFGD MEDLTDEEEV PASQSTENRV LPAPAPRREK TNEELQEELR
   121  NLQEQMKALQ EQLKVTTIKQ TASPARLQKS PVEKSPRPPL KERRVQRIQE STCFSAELDV
   181  PALPRTKRVA RTPKASPPDP KSSSSRMTSA PSQPLQTISR NKPSGITRGQ IVGTPGSSGE
   241  TTQPICVEAF SGLRLRRPRV SSTEMNKKMT GRKLIRLSQI KEKMAREKLE EIDWVTFGVI
   301  LKKVTPQSVN SGKTFSIWKL NDLRDLTQCV SLFLFGEVHK ALWKTEQGTV VGILNANPMK
   361  PKDGSEEVCL SIDHPQKVLI MGEALDLGTC KAKKKNGEPC TQTVNLRDCE YCQYHVQAQY
   421  KKLSAKRADL QSTFSGGRIP KKFARRGTSL KERLCQDGFY YGGVSSASYA ASIAAAVAPK
   481  KKIQTTLSNL VVKGTNLIIQ ETRQKLGIPQ KSLSCSEEFK ELMDLPTCGA RNLKQHLAKA
   541  TASGIMGSPK PAIKSISASA LLKQQKQRML EMRRRKSEEI QKRFLQSSSE VESPAVPSSS
   601  RQPPAQPPRT GSEFPRLEGA PATMTPKLGR GVLEGDDVLF YDESPPPRPK LSALAEAKKL
   661  AAITKLRAKG QVLTKTNPNS IKKKQKDPQD ILEVKERVEK NTMFSSQAED ELEPARKKRR
   721  EQLAYLESEE FQKILKAKSK HTGILKEAEA EMQERYFEPL VKKEQMEEKM RNIREVKCRV
   781  VTCKTCAYTH FKLLETCVSE QHEYHWHDGV KRFFKCPCGN RSISLDRLPN KHCSNCGLYK
   841  WERDGMLKEK TGPKIGGETL LPRGEEHAKF LNSLK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MCM10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 8.7 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 8.7 nTPM
thymus: 7.5 nTPM
lymph node: 4.5 nTPM
tonsil: 4.2 nTPM
appendix: 3.1 nTPM
placenta: 2 nTPM

Single-cell type

erythrocyte progenitors: 97 nCPM
megakaryocyte progenitors: 63 nCPM
monocyte progenitors: 48 nCPM
early primary spermatocytes: 32 nCPM
extravillous trophoblasts: 28 nCPM
migrating cytotrophoblasts: 27 nCPM

Immune cell

memory CD8 T-cell: 0.9 nTPM
naive CD8 T-cell: 0.7 nTPM
memory CD4 T-cell: 0.4 nTPM
neutrophil: 0.4 nTPM
T-reg: 0.4 nTPM
total PBMC: 0.4 nTPM

Brain region

cerebral cortex: 1.6 nTPM
choroid plexus: 1.6 nTPM
thalamus: 1.6 nTPM
cerebellum: 1.5 nTPM
pons: 1.5 nTPM
white matter: 1.4 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MCM10.

Disease | AllUniProt

Conditions MCM10 is implicated in, by any mechanism.

Immunodeficiency 80 with or without congenital cardiomyopathy (IMD80) MIM:619313

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 188 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Immunodeficiency 80 with or without congenital cardiomyopathy
Fetal Cardiomyopathy

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.84
gnomAD pLI: 0
gnomAD missense Z: -0.17
DepMap mean gene effect: -0.73
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Nucleic acid-binding, OB-fold
Zinc finger, Mcm10/DnaG-type
Replication factor Mcm10, C-terminal
Minichromosome maintenance protein 10
MCM10, OB-fold
Mcm10, C-terminal zinc binding motif
Primase zinc finger
Mcm10, C-terminal zinc binding motif
MCM10 OB-fold
Mcm10, CCCH-type zinc motif

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MCM10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MCM10 as an antibody target. Whether an autoantibody or antibody against MCM10 could matter depends on whether native MCM10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MCM10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MCM10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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