Seroatlas · Human Serome Atlas

FAM124B

Protein FAM124B

Also known as: F124B_HUMAN, FLJ22746

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H5Z6
Gene: FAM124B
Ensembl: ENSG00000124019
Chromosome: 2
Canonical length: 455 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Mitochondria

OverviewNCBI Gene

Located in mitochondrion and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

455 residues, UniProt reviewed canonical sequence.

>Q9H5Z6|FAM124B
     1  MDETQGPLAM TVHLLANSGH GSLLQRTLDQ LLDCICPEVR LFQVSERASP VKYCEKSHSK
    61  RSRFPGMSVL LFLHESPGED RLFRVLDSLQ HSPWQCYPTQ DTRGRLCPYF FANQEFYSLD
   121  SQLPIWGVRQ VHCGSEILRV TLYCSFDNYE DAIRLYEMIL QREATLQKSN FCFFVLYASK
   181  SFALQLSLKQ LPPGMSVDPK ESSVLQFKVQ EIGQLVPLLP NPCMPISSTR WQTQDYDGNK
   241  ILLQVQLNPE LGVKNGILGA GMLPLGSRLT SVSAKRTSEP RSQRNQGKRS QGHSLELPEP
   301  SGSPTSDRCA GTSWKSPGRS FQVSSPAMGA HLHLSSHHLE SGARMKVLNR ENSFQKLEAE
   361  TNVDTGLTII NSEPRQTYFG GFPRDLQTSQ PPFCLPASSL GVATSKNNSV LKERVSPLPL
   421  AGQRDLGTRK TISECLLHLQ VQGEEKEEDE EEFFI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM124B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 8 nTPM

Expression across tissuesHPA

Tissue

placenta: 8 nTPM
adipose tissue: 4.8 nTPM
bone marrow: 4.5 nTPM
tongue: 4.3 nTPM
breast: 4.1 nTPM
parathyroid gland: 2.3 nTPM

Single-cell type

megakaryocyte-erythroid progenitors: 168 nCPM
hematopoietic stem cells: 62 nCPM
erythrocyte progenitors: 52 nCPM
megakaryocyte progenitors: 27 nCPM
vascular endothelial cells: 16 nCPM
innate lymphoid cells: 13 nCPM

Immune cell

basophil: 30 nTPM
eosinophil: 17 nTPM
myeloid DC: 7.9 nTPM
NK-cell: 5.4 nTPM
classical monocyte: 3 nTPM
T-reg: 2.5 nTPM

Brain region

medulla oblongata: 3.8 nTPM
midbrain: 3.5 nTPM
thalamus: 3.5 nTPM
spinal cord: 3.4 nTPM
hypothalamus: 3.3 nTPM
cerebral cortex: 3.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.3
gnomAD pLI: 0
gnomAD missense Z: 0.68
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FAM124B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM124B as an antibody target. Whether an autoantibody or antibody against FAM124B could matter depends on whether native FAM124B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM124B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM124B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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