Seroatlas · Human Serome Atlas

AKTIP

AKT-interacting protein

Also known as: AKTIP_HUMAN, FLJ13258, FTS

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H8T0
Gene: AKTIP
Ensembl: ENSG00000166971
Chromosome: 16
Canonical length: 292 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoli,Golgi apparatus,Plasma membrane,Basal body,Cytosol

OverviewNCBI Gene

The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

292 residues, UniProt reviewed canonical sequence.

>Q9H8T0|AKTIP
     1  MNPFWSMSTS SVRKRSEGEE KTLTGDVKTS PPRTAPKKQL PSIPKNALPI TKPTSPAPAA
    61  QSTNGTHASY GPFYLEYSLL AEFTLVVKQK LPGVYVQPSY RSALMWFGVI FIRHGLYQDG
   121  VFKFTVYIPD NYPDGDCPRL VFDIPVFHPL VDPTSGELDV KRAFAKWRRN HNHIWQVLMY
   181  ARRVFYKIDT ASPLNPEAAV LYEKDIQLFK SKVVDSVKVC TARLFDQPKI EDPYAISFSP
   241  WNPSVHDEAR EKMLTQKKPE EQHNKSVHVA GLSWVKPGSV QPFSKEEKTV AT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AKTIP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 126 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 126 nTPM
tongue: 76 nTPM
retina: 71 nTPM
amygdala: 63 nTPM
midbrain: 62 nTPM
spinal cord: 61 nTPM

Single-cell type

late spermatids: 495 nCPM
early spermatids: 225 nCPM
esophageal apical cells: 130 nCPM
cytotrophoblasts: 95 nCPM
oocytes: 88 nCPM
syncytiotrophoblasts: 86 nCPM

Immune cell

naive CD4 T-cell: 48 nTPM
T-reg: 47 nTPM
naive CD8 T-cell: 39 nTPM
memory CD8 T-cell: 34 nTPM
gdT-cell: 33 nTPM
memory CD4 T-cell: 31 nTPM

Brain region

pons: 93 nTPM
cerebral cortex: 87 nTPM
white matter: 86 nTPM
thalamus: 84 nTPM
medulla oblongata: 84 nTPM
spinal cord: 83 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.5
gnomAD pLI: 0.4
gnomAD missense Z: 1.74
DepMap mean gene effect: -0.21
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ubiquitin conjugating enzyme activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AKTIP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AKTIP as an antibody target. Whether an autoantibody or antibody against AKTIP could matter depends on whether native AKTIP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AKTIP is annotated at the cell surface, where native AKTIP is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label AKTIP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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