Importin beta family

Definition

This family consists of the karyopherins importin-beta and transportin. Importin subunit beta-1 forms a complex with an importin alpha subunit. The importin complex is required for nuclear protein import. Importins bind to NLSs in their protein cargos to transport them through the nuclear pore into the nucleus PMID:26173234. Transportin-1 and -2 also function in nuclear import PMID:24780099. Transportin-1 was first identified as the import factor for the heterogeneous ribonucleoprotein A1 (hnRNP A1) PMID:9298975. The subfamily of proteins known as RanBP6 (Ran-binding protein 6) are part of this family PMID:29229958.

6 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (6 proteins: gene, accession, name)

• IPO4
• IPO5
• KPNB1
• RANBP6
• TNPO1
• TNPO2