Importin subunit beta-1/Transportin-1-like, TPR repeats

Definition

This is a region of tetratricopeptide (TPR)-like repeats found in human Importin subunit beta-1 (IMB1).Transportin-1 (TNPO1) and similar eukaryotic proteins. IMB1 functions in nuclear protein import, either in association with an adapter protein, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor [[cite:PMID:11682607], [cite:PMID:11891849], [cite:PMID:19386897], [cite:PMID:20818336], [cite:PMID:24699649]]. TNPO1 functions in nuclear protein import as nuclear transport receptor. It serves as receptor for nuclear localisation signals (NLS) in cargo substrates PMID:24753571.

6 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (6 proteins: gene, accession, name)

• IPO4
• IPO5
• KPNB1
• RANBP6
• TNPO1
• TNPO2