Seroatlas · Human Serome Atlas

TMA16

Translation machinery-associated protein 16

Also known as: C4orf43, FLJ11184, TMA16_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96EY4
Gene: TMA16
Ensembl: ENSG00000198498
Chromosome: 4
Canonical length: 203 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

Enables preribosome binding activity. Involved in ribosomal large subunit biogenesis. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

203 residues, UniProt reviewed canonical sequence.

>Q96EY4|TMA16
     1  MPKAPKGKSA GREKKVIHPY SRKAAQITRE AHKQEKKEKL KNEKALRLNL VGEKLQWFQN
    61  HLDPQKKRYS KKDACELIER YLNRFSSELE QIELHNSIRD RQGRRHCSRE TVIKQTMERE
   121  RQQFEGYGLE IPDILNASNL KTFREWDFDL KKLPNIKMRK ICANDAIPKT CKRKTIITVD
   181  QDLGELELND ESSDSDEEMT AVA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMA16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

testis: 26 nTPM
lymph node: 21 nTPM
ovary: 19 nTPM
tonsil: 19 nTPM
thymus: 18 nTPM
appendix: 17 nTPM

Single-cell type

late spermatids: 252 nCPM
late primary spermatocytes: 228 nCPM
megakaryocytes: 161 nCPM
early spermatids: 161 nCPM
hepatic stellate cells: 116 nCPM
extravillous trophoblasts: 110 nCPM

Immune cell

plasmacytoid DC: 75 nTPM
intermediate monocyte: 59 nTPM
memory B-cell: 56 nTPM
naive B-cell: 52 nTPM
non-classical monocyte: 49 nTPM
myeloid DC: 42 nTPM

Brain region

white matter: 11 nTPM
cerebellum: 9.7 nTPM
choroid plexus: 9.2 nTPM
hypothalamus: 9 nTPM
pons: 8.8 nTPM
spinal cord: 8.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.14
gnomAD pLI: 0
gnomAD missense Z: 0.36
DepMap mean gene effect: -0.74
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

ribosomal large subunit biogenesis

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Translation machinery-associated protein 16
Tma16 superfamily
Translation machinery-associated protein 16

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMA16 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMA16 as an antibody target. Whether an autoantibody or antibody against TMA16 could matter depends on whether native TMA16 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMA16 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMA16 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...