Seroatlas · Human Serome Atlas

HSH2D

Hematopoietic SH2 domain-containing protein

Also known as: ALX, FLJ14886, HSH2, HSH2D_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96JZ2
Gene: HSH2D
Ensembl: ENSG00000196684
Chromosome: 19
Canonical length: 352 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Focal adhesion sites,Cytosol

OverviewNCBI Gene

T-cell activation requires 2 signals: recognition of antigen by the T-cell receptor (see TCR; MIM 186880) and a costimulatory signal provided primarily by CD28 (MIM 186760) in naive T cells. HSH2 is a target of both of these signaling pathways (Greene et al., 2003 [PubMed 12960172]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

352 residues, UniProt reviewed canonical sequence.

>Q96JZ2|HSH2D
     1  MTEAGKLPLP LPPRLDWFVH TQMGQLAQDG VPEWFHGAIS REDAENLLES QPLGSFLIRV
    61  SHSHVGYTLS YKAQSSCCHF MVKLLDDGTF MIPGEKVAHT SLDALVTFHQ QKPIEPRREL
   121  LTQPCRQKDP ANVDYEDLFL YSNAVAEEAA CPVSAPEEAS PKPVLCHQSK ERKPSAEMNR
   181  ITTKEATSSC PPKSPLGETR QKLWRSLKML PERGQRVRQQ LKSHLATVNL SSLLDVRRST
   241  VISGPGTGKG SQDHSGDPTS GDRGYTDPCV ATSLKSPSQP QAPKDRKVPT RKAERSVSCI
   301  EVTPGDRSWH QMVVRALSSQ ESKPEHQGLA EPENDQLPEE YQQPPPFAPG YC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HSH2D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 44 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 44 nTPM
spleen: 36 nTPM
tonsil: 34 nTPM
lymph node: 25 nTPM
small intestine: 19 nTPM
appendix: 16 nTPM

Single-cell type

plasma cells: 227 nCPM
thymocytes: 207 nCPM
nk-cells: 206 nCPM
hematopoietic stem cells: 133 nCPM
megakaryocyte-erythroid progenitors: 112 nCPM
b-cells: 100 nCPM

Immune cell

basophil: 233 nTPM
neutrophil: 183 nTPM
eosinophil: 101 nTPM
NK-cell: 85 nTPM
memory B-cell: 57 nTPM
non-classical monocyte: 39 nTPM

Brain region

white matter: 9 nTPM
medulla oblongata: 6.5 nTPM
cerebral cortex: 6.4 nTPM
choroid plexus: 5.8 nTPM
basal ganglia: 5.5 nTPM
pons: 5.5 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

protein-macromolecule adaptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

SH2 domain
SH2 domain superfamily
SH2 domain
Hematopoietic SH2 domain-containing protein, Src homology 2 domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HSH2D in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HSH2D as an antibody target. Whether an autoantibody or antibody against HSH2D could matter depends on whether native HSH2D is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HSH2D is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HSH2D as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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