CXCL11

Protein identityUniProt · HPA

UniProt accession

O14625

Gene

CXCL11

Ensembl

ENSG00000169248

Chromosome

4

Canonical length

94 aa

Protein class

Human disease related genes, Predicted secreted proteins

Secretome location

Secreted to blood

OverviewNCBI Gene

Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC. This antimicrobial gene is a CXC member of the chemokine superfamily. Its encoded protein induces a chemotactic response in activated T-cells and is the dominant ligand for CXC receptor-3. The gene encoding this protein contains 4 exons and at least three polyadenylation signals which might reflect cell-specific regulation of expression. IFN-gamma is a potent inducer of transcription of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]

Canonical amino-acid sequenceUniProt

94 residues, UniProt reviewed canonical sequence.

>O14625|CXCL11
     1  MSVKGMAIAL AVILCATVVQ GFPMFKRGRC LCIGPGVKAV KVADIEKASI MYPSNNCDKI
    61  EVIITLKENK GQRCLNPKSK QARLIIKKVE RKNF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CXCL11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.46

Highest tissue expression

11 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.14

gnomAD pLI

0.31

gnomAD missense Z

0.32

DepMap mean gene effect

-0.01

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• adenylate cyclase-activating G protein-coupled receptor signaling pathway
• cell-cell signaling
• chemokine-mediated signaling pathway
• chemotaxis
• immune response
• inflammatory response
• positive regulation of release of sequestered calcium ion into cytosol
• regulation of cell population proliferation
• signal transduction
• T cell chemotaxis

Molecular functions

• chemokine activity
• CXCR chemokine receptor binding
• CXCR3 chemokine receptor binding
• heparin binding

Cellular components

• extracellular region
• extracellular space
• membrane

Protein domainsUniProt · Pfam · InterPro

• CXC chemokine
• Chemokine interleukin-8-like domain
• CXC chemokine, conserved site
• CXC Chemokine domain
• Chemokine interleukin-8-like superfamily
• Chemokine beta/gamma/delta
• Small cytokines (intecrine/chemokine), interleukin-8 like

KeywordsUniProt

• Chemotaxis
• Citrullination
• Cytokine
• Disulfide bond
• Inflammatory response
• Secreted
• Signal

InteractionsUniProt · HPA

Protein binding partners of CXCL11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• TNFAIP6