Seroatlas · Human Serome Atlas

CCL7

C-C motif chemokine 7

Also known as: CCL7_HUMAN, FIC, MARC, MCP-3, MCP3, NC28, SCYA6, SCYA7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P80098
Gene: CCL7
Ensembl: ENSG00000108688
Chromosome: 17
Canonical length: 99 aa
Protein class: Cancer-related genes, Predicted membrane proteins, Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

This gene encodes monocyte chemotactic protein 3, a secreted chemokine which attracts macrophages during inflammation and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent cysteine residues. The protein is an in vivo substrate of matrix metalloproteinase 2, an enzyme which degrades components of the extracellular matrix. This gene is part of a cluster of C-C chemokine family members on chromosome 17q. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

99 residues, UniProt reviewed canonical sequence.

>P80098|CCL7
     1  MKASAALLCL LLTAAAFSPQ GLAQPVGINT STTCCYRFIN KKIPKQRLES YRRTTSSHCP
    61  REAVIFKTKL DKEICADPTQ KWVQDFMKHL DKKTQTPKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCL7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 24 nTPM
urinary bladder: 2.9 nTPM
appendix: 2.3 nTPM
lung: 0.9 nTPM
rectum: 0.9 nTPM
adipose tissue: 0.8 nTPM

Single-cell type

fallopian secretory cells: 17 nCPM
pancreatic duct cells: 15 nCPM
epididymal efferent duct ciliated cells: 8.8 nCPM
mesothelial cells: 8.2 nCPM
monocytes: 7.1 nCPM
epididymal basal cells: 6.3 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

thalamus: 5 nTPM
cerebral cortex: 0.8 nTPM
pons: 0.2 nTPM
medulla oblongata: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.91
gnomAD pLI: 0
gnomAD missense Z: -0.14
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCL7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TNFAIP6

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCL7 as an antibody target. Whether an autoantibody or antibody against CCL7 could matter depends on whether native CCL7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCL7 is annotated as secreted, so native CCL7 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CCL7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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