Seroatlas · Human Serome Atlas

CCL27

C-C motif chemokine 27

Also known as: ALP, CCL27_HUMAN, CTACK, CTAK, ESkine, ILC, PESKY, SCYA27, skinkine

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y4X3
Gene: CCL27
Ensembl: ENSG00000213927
Chromosome: 9
Canonical length: 112 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene is chemotactic for skin-associated memory T lymphocytes. This cytokine may also play a role in mediating homing of lymphocytes to cutaneous sites. It specifically binds to chemokine receptor 10 (CCR10). Studies of a similar murine protein indicate that these protein-receptor interactions have a pivotal role in T cell-mediated skin inflammation. [provided by RefSeq, Sep 2014]

Canonical amino-acid sequenceUniProt

112 residues, UniProt reviewed canonical sequence.

>Q9Y4X3|CCL27
     1  MKGPPTFCSL LLLSLLLSPD PTAAFLLPPS TACCTQLYRK PLSDKLLRKV IQVELQEADG
    61  DCHLQAFVLH LAQRSICIHP QNPSLSQWFE HQERKLHGTL PKLNFGMLRK MG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCL27 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 457 nTPM

Expression across tissuesHPA

Tissue

skin: 457 nTPM
breast: 26 nTPM
thymus: 4.3 nTPM
epididymis: 2.9 nTPM
bone marrow: 1.5 nTPM
skeletal muscle: 1.3 nTPM

Single-cell type

basal keratinocytes: 4.8 nCPM
suprabasal keratinocytes: 2.9 nCPM
astrocytes: 0.9 nCPM
bergmann glia: 0.8 nCPM
brain excitatory neurons: 0.3 nCPM
brain inhibitory neurons: 0.3 nCPM

Immune cell

T-reg: 0.3 nTPM
naive B-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebellum: 5.6 nTPM
cerebral cortex: 2.8 nTPM
white matter: 2.8 nTPM
medulla oblongata: 2.4 nTPM
pons: 2.3 nTPM
midbrain: 2.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.65
gnomAD pLI: 0.01
gnomAD missense Z: 0.41
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCL27 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TNFAIP6

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCL27 as an antibody target. Whether an autoantibody or antibody against CCL27 could matter depends on whether native CCL27 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCL27 is annotated as secreted, so native CCL27 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CCL27 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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