Seroatlas · Human Serome Atlas

CCL19

C-C motif chemokine 19

Also known as: CCL19_HUMAN, CKb11, ELC, exodus-3, MIP-3b, SCYA19

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q99731
Gene: CCL19
Ensembl: ENSG00000172724
Chromosome: 9
Canonical length: 98 aa
Protein class: Cancer-related genes, Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7. [provided by RefSeq, Sep 2014]

Canonical amino-acid sequenceUniProt

98 residues, UniProt reviewed canonical sequence.

>Q99731|CCL19
     1  MALLLALSLL VLWTSPAPTL SGTNDAEDCC LSVTQKPIPG YIVRNFHYLL IKDGCRVPAV
    61  VFTTLRGRQL CAPPDQPWVE RIIQRLQRTS AKMKRRSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCL19 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 591 nTPM

Expression across tissuesHPA

Tissue

lymph node: 591 nTPM
appendix: 574 nTPM
tonsil: 565 nTPM
thymus: 491 nTPM
blood vessel: 152 nTPM
small intestine: 142 nTPM

Single-cell type

pericytes: 219 nCPM
medullary thymic epithelial cells: 79 nCPM
fibroblasts: 48 nCPM
vascular smooth muscle cells: 34 nCPM
cdc: 11 nCPM
hepatic stellate cells: 6.5 nCPM

Immune cell

intermediate monocyte: 0.3 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 7.2 nTPM
medulla oblongata: 5 nTPM
pons: 4.8 nTPM
basal ganglia: 3.1 nTPM
thalamus: 2.9 nTPM
amygdala: 2.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.13
gnomAD pLI: 0.32
gnomAD missense Z: 1.15
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCL19 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TNFAIP6

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCL19 as an antibody target. Whether an autoantibody or antibody against CCL19 could matter depends on whether native CCL19 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCL19 is annotated as secreted, so native CCL19 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CCL19 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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