Seroatlas · Human Serome Atlas

ELOVL3

Very long chain fatty acid elongase 3

Also known as: CIG-30, ELOV3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HB03
Gene: ELOVL3
Ensembl: ENSG00000119915
Chromosome: 10
Canonical length: 270 aa
Protein class: Enzymes, Metabolic proteins, Predicted membrane proteins
Subcellular location: Vesicles,Cytosol

OverviewNCBI Gene

This gene encodes a protein that belongs to the GNS1/SUR4 family. Members of this family play a role in elongation of long chain fatty acids to provide precursors for synthesis of sphingolipids and ceramides. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

270 residues, UniProt reviewed canonical sequence.

>Q9HB03|ELOVL3
     1  MVTAMNVSHE VNQLFQPYNF ELSKDMRPFF EEYWATSFPI ALIYLVLIAV GQNYMKERKG
    61  FNLQGPLILW SFCLAIFSIL GAVRMWGIMG TVLLTGGLKQ TVCFINFIDN STVKFWSWVF
   121  LLSKVIELGD TAFIILRKRP LIFIHWYHHS TVLVYTSFGY KNKVPAGGWF VTMNFGVHAI
   181  MYTYYTLKAA NVKPPKMLPM LITSLQILQM FVGAIVSILT YIWRQDQGCH TTMEHLFWSF
   241  ILYMTYFILF AHFFCQTYIR PKVKAKTKSQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ELOVL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

skin: 28 nTPM
breast: 3.3 nTPM
adipose tissue: 3 nTPM
bone marrow: 1.7 nTPM
testis: 1.2 nTPM
amygdala: 1.1 nTPM

Single-cell type

oocytes: 18 nCPM
monocyte progenitors: 4.9 nCPM
neutrophil progenitors: 4.9 nCPM
undifferentiated spermatogonia: 4.5 nCPM
breast myoepithelial cells: 4.3 nCPM
endometrial secretory cells: 4.2 nCPM

Immune cell

classical monocyte: 7.1 nTPM
non-classical monocyte: 6 nTPM
intermediate monocyte: 2.4 nTPM
myeloid DC: 2 nTPM
total PBMC: 1.7 nTPM
neutrophil: 0.4 nTPM

Brain region

amygdala: 1.4 nTPM
cerebral cortex: 1.4 nTPM
midbrain: 1.2 nTPM
basal ganglia: 0.9 nTPM
hippocampal formation: 0.9 nTPM
white matter: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.04
gnomAD pLI: 0.02
gnomAD missense Z: 0.75
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

fatty acid elongase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

ELO family
ELO family, conserved site
GNS1/SUR4 family
Elongation of very long chain fatty acids protein 3

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ELOVL3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TECR

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ELOVL3 as an antibody target. Whether an autoantibody or antibody against ELOVL3 could matter depends on whether native ELOVL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ELOVL3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ELOVL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...