3-oxo-5-alpha-steroid 4-dehydrogenase

Definition

This family consists of 3-oxo-5-alpha-steroid 4-dehydrogenases, [ec:1.3.99.5] Also known as Steroid 5-alpha-reductase, the reaction catalysed by this enzyme is: 3-oxo-5-alpha-steroid + acceptor 3-oxo-delta(4)-steroid + reduced acceptor. The Steroid 5-alpha-reductase enzyme is responsible for the formation of dihydrotestosterone, this hormone promotes the differentiation of male external genitalia and the prostate during fetal development PMID:1686016. In humans mutations in this enzyme can cause a form of male pseudohermaphorditism in which the external genitalia and prostate fail to develop normally PMID:1686016. A related enzyme is also found in plants is [swissprot:Q38944] (DET2) a steroid reductase from Arabidopsis. Mutations in this enzyme cause defects in light-regulated development PMID:8602526.

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• SRD5A1
• SRD5A2
• SRD5A3
• TECR
• TECRL