Seroatlas · Human Serome Atlas

ELOVL2

Very long chain fatty acid elongase 2

Also known as: ELOV2_HUMAN, Ssc2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NXB9
Gene: ELOVL2
Ensembl: ENSG00000197977
Chromosome: 6
Canonical length: 296 aa
Protein class: Enzymes, Metabolic proteins, Predicted membrane proteins

OverviewNCBI Gene

Enables fatty acid elongase activity. Involved in fatty acid elongation, polyunsaturated fatty acid and very long-chain fatty acid biosynthetic process. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

296 residues, UniProt reviewed canonical sequence.

>Q9NXB9|ELOVL2
     1  MEHLKAFDDE INAFLDNMFG PRDSRVRGWF MLDSYLPTFF LTVMYLLSIW LGNKYMKNRP
    61  ALSLRGILTL YNLGITLLSA YMLAELILST WEGGYNLQCQ DLTSAGEADI RVAKVLWWYY
   121  FSKSVEFLDT IFFVLRKKTS QITFLHVYHH ASMFNIWWCV LNWIPCGQSF FGPTLNSFIH
   181  ILMYSYYGLS VFPSMHKYLW WKKYLTQAQL VQFVLTITHT MSAVVKPCGF PFGCLIFQSS
   241  YMLTLVILFL NFYVQTYRKK PMKKDMQEPP AGKEVKNGFS KAYFTAANGV MNKKAQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ELOVL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 49 nTPM

Expression across tissuesHPA

Tissue

liver: 49 nTPM
placenta: 33 nTPM
retina: 26 nTPM
spinal cord: 20 nTPM
cerebral cortex: 13 nTPM
basal ganglia: 13 nTPM

Single-cell type

epicardial cells: 293 nCPM
bergmann glia: 279 nCPM
oocytes: 272 nCPM
cone photoreceptor cells: 162 nCPM
astrocytes: 129 nCPM
pituicytes/fscs: 128 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 23 nTPM
cerebral cortex: 17 nTPM
basal ganglia: 17 nTPM
medulla oblongata: 17 nTPM
cerebellum: 15 nTPM
spinal cord: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.37
gnomAD pLI: 0
gnomAD missense Z: 0.07
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

fatty acid elongase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

ELO family
ELO family, conserved site
GNS1/SUR4 family
Elongation of very long chain fatty acids protein 2

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ELOVL2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TECR

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ELOVL2 as an antibody target. Whether an autoantibody or antibody against ELOVL2 could matter depends on whether native ELOVL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ELOVL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ELOVL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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