Seroatlas · Human Serome Atlas

ELOVL7

Very long chain fatty acid elongase 7

Also known as: ELOV7_HUMAN, FLJ23563

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A1L3X0
Gene: ELOVL7
Ensembl: ENSG00000164181
Chromosome: 5
Canonical length: 281 aa
Protein class: Enzymes, Metabolic proteins, Predicted membrane proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables fatty acid elongase activity. Involved in fatty acid elongation, polyunsaturated fatty acid; fatty acid elongation, saturated fatty acid; and very long-chain fatty acid biosynthetic process. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

281 residues, UniProt reviewed canonical sequence.

>A1L3X0|ELOVL7
     1  MAFSDLTSRT VHLYDNWIKD ADPRVEDWLL MSSPLPQTIL LGFYVYFVTS LGPKLMENRK
    61  PFELKKAMIT YNFFIVLFSV YMCYEFVMSG WGIGYSFRCD IVDYSRSPTA LRMARTCWLY
   121  YFSKFIELLD TIFFVLRKKN SQVTFLHVFH HTIMPWTWWF GVKFAAGGLG TFHALLNTAV
   181  HVVMYSYYGL SALGPAYQKY LWWKKYLTSL QLVQFVIVAI HISQFFFMED CKYQFPVFAC
   241  IIMSYSFMFL LLFLHFWYRA YTKGQRLPKT VKNGTCKNKD N

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ELOVL7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 32 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 32 nTPM
skin: 25 nTPM
choroid plexus: 24 nTPM
midbrain: 22 nTPM
breast: 21 nTPM
prostate: 21 nTPM

Single-cell type

platelets: 467 nCPM
endometrial luminal cells: 352 nCPM
choroid plexus epithelial cells: 347 nCPM
epicardial cells: 287 nCPM
renal collecting duct intercalated cells: 231 nCPM
distal convoluted tubule cells: 231 nCPM

Immune cell

total PBMC: 2.5 nTPM
basophil: 1.9 nTPM
neutrophil: 1.3 nTPM
eosinophil: 0.3 nTPM
classical monocyte: 0.1 nTPM
gdT-cell: 0 nTPM

Brain region

choroid plexus: 67 nTPM
thalamus: 61 nTPM
pons: 60 nTPM
white matter: 56 nTPM
medulla oblongata: 55 nTPM
spinal cord: 54 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.75
gnomAD pLI: 0.01
gnomAD missense Z: 0.9
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

fatty acid elongase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

ELO family
ELO family, conserved site
GNS1/SUR4 family
Elongation of very long chain fatty acids protein 7

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ELOVL7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TECR

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ELOVL7 as an antibody target. Whether an autoantibody or antibody against ELOVL7 could matter depends on whether native ELOVL7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ELOVL7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ELOVL7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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