3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal
IPR001104
Definition
3-oxo-5-alpha-steroid 4-dehydrogenases, [ec:1.3.99.5] catalyse the conversion of 3-oxo-5-alpha-steroid + acceptor to 3-oxo-delta(4)-steroid + reduced acceptor. The steroid 5-alpha-reductase enzyme is responsible for the formation of dihydrotestosterone, this hormone promotes the differentiation of male external genitalia and the prostate during foetal development PMID:1686016. In humans mutations in this enzyme can cause a form of male pseudohermaphorditism in which the external genitalia and prostate fail to develop normally. A related steroid reductase enzyme, DET2, is found in plants such as Arabidopsis. Mutations in this enzyme cause defects in light-regulated development PMID:8602526. This domain is present in both type 1 and type 2 PMID:1944596 forms. This domain is also found in polyprenol reductase (SRD5A3; [ec:1.3.1.94]), which is reduces the alpha-isoprene unit of polyprenol to form dolichol. Dolichol is required for the synthesis of a dolichol-linked monosaccharide and the oligosaccharide precursor used for N-glycosylation PMID:20637498. Another enzyme with this domain is very-long-chain enoyl-CoA reductase (TECR; [ec:1.3.1.93]), which catalyses the last of the four reactions of the long-chain fatty acids elongation cycle by reducing the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation PMID:12482854.
5 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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