Seroatlas · Human Serome Atlas

HACD2

Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2

Also known as: HACD2_HUMAN, PTPLB

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6Y1H2
Gene: HACD2
Ensembl: ENSG00000206527
Chromosome: 3
Canonical length: 254 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene can catalyze the third step (dehydration) in the conversion of long chain fatty acids to very long chain fatty acids. The encoded protein localizes to the endoplasmic reticulum membrane. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

254 residues, UniProt reviewed canonical sequence.

>Q6Y1H2|HACD2
     1  MAAVAATAAA KGNGGGGGRA GAGDASGTRK KKGPGPLATA YLVIYNVVMT AGWLVIAVGL
    61  VRAYLAKGSY HSLYYSIEKP LKFFQTGALL EILHCAIGIV PSSVVLTSFQ VMSRVFLIWA
   121  VTHSVKEVQS EDSVLLFVIA WTITEIIRYS FYTFSLLNHL PYLIKWARYT LFIVLYPMGV
   181  SGELLTIYAA LPFVRQAGLY SISLPNKYNF SFDYYAFLIL IMISYIPIFP QLYFHMIHQR
   241  RKILSHTEEH KKFE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HACD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 64 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 64 nTPM
liver: 45 nTPM
skin: 31 nTPM
duodenum: 28 nTPM
prostate: 28 nTPM
tonsil: 27 nTPM

Single-cell type

adipocytes: 328 nCPM
esophageal apical cells: 111 nCPM
alveolar cells type 2: 108 nCPM
prostatic glandular cells: 106 nCPM
alveolar cells type 1: 94 nCPM
sertoli cells: 94 nCPM

Immune cell

myeloid DC: 2.8 nTPM
T-reg: 2.5 nTPM
MAIT T-cell: 2.2 nTPM
naive B-cell: 2 nTPM
memory CD4 T-cell: 1.9 nTPM
memory CD8 T-cell: 1.9 nTPM

Brain region

white matter: 69 nTPM
basal ganglia: 49 nTPM
medulla oblongata: 44 nTPM
hypothalamus: 42 nTPM
cerebellum: 40 nTPM
pons: 39 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.74
gnomAD pLI: 0.07
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HACD2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HACD2 as an antibody target. Whether an autoantibody or antibody against HACD2 could matter depends on whether native HACD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HACD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HACD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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