Seroatlas · Human Serome Atlas

AURKC

Aurora kinase C

Also known as: ARK3, AurC, AURKC_HUMAN, STK13

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UQB9
Gene
AURKC
Ensembl
ENSG00000105146
Chromosome
19
Canonical length
309 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

309 residues, UniProt reviewed canonical sequence.

>Q9UQB9|AURKC
     1  MSSPRAVVQL GKAQPAGEEL ATANQTAQQP SSPAMRRLTV DDFEIGRPLG KGKFGNVYLA
    61  RLKESHFIVA LKVLFKSQIE KEGLEHQLRR EIEIQAHLQH PNILRLYNYF HDARRVYLIL
   121  EYAPRGELYK ELQKSEKLDE QRTATIIEEL ADALTYCHDK KVIHRDIKPE NLLLGFRGEV
   181  KIADFGWSVH TPSLRRKTMC GTLDYLPPEM IEGRTYDEKV DLWCIGVLCY ELLVGYPPFE
   241  SASHSETYRR ILKVDVRFPL SMPLGARDLI SRLLRYQPLE RLPLAQILKH PWVQAHSRRV
   301  LPPCAQMAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AURKC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
45 nTPM

Expression across tissuesHPA

Tissue

  • testis: 45 nTPM
  • spleen: 4.7 nTPM
  • spinal cord: 3.6 nTPM
  • choroid plexus: 3.5 nTPM
  • lymph node: 3.3 nTPM
  • liver: 2.5 nTPM

Single-cell type

  • late primary spermatocytes: 290 nCPM
  • early spermatids: 121 nCPM
  • oocytes: 65 nCPM
  • early primary spermatocytes: 34 nCPM
  • late spermatids: 27 nCPM
  • undifferentiated spermatogonia: 21 nCPM

Immune cell

  • eosinophil: 0.4 nTPM
  • memory B-cell: 0.3 nTPM
  • naive B-cell: 0.3 nTPM
  • intermediate monocyte: 0.2 nTPM
  • myeloid DC: 0.2 nTPM
  • NK-cell: 0.2 nTPM

Brain region

  • white matter: 3.6 nTPM
  • pons: 3.5 nTPM
  • cerebellum: 2.5 nTPM
  • spinal cord: 2.5 nTPM
  • basal ganglia: 2.3 nTPM
  • cerebral cortex: 2.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about AURKC.

Disease | AllUniProt

Conditions AURKC is implicated in, by any mechanism.

Disease | GeneticClinVar

7 pathogenic / likely-pathogenic of 89 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.73
gnomAD pLI
0.08
gnomAD missense Z
0.5
DepMap mean gene effect
0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AURKC in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AURKC as an antibody target. Whether an autoantibody or antibody against AURKC could matter depends on whether native AURKC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AURKC is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AURKC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/AURKC. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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