Seroatlas · Human Serome Atlas

CCNL2

Cyclin-L2

Also known as: ania-6b, CCNL2_HUMAN, CCNM, CCNS, HLA-ISO, PCEE, SB138

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96S94
Gene: CCNL2
Ensembl: ENSG00000221978
Chromosome: 1
Canonical length: 520 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

The protein encoded by this gene belongs to the cyclin family. Through its interaction with several proteins, such as RNA polymerase II, splicing factors, and cyclin-dependent kinases, this protein functions as a regulator of the pre-mRNA splicing process, as well as in inducing apoptosis by modulating the expression of apoptotic and antiapoptotic proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

520 residues, UniProt reviewed canonical sequence.

>Q96S94|CCNL2
     1  MAAAAAAAGA AGSAAPAAAA GAPGSGGAPS GSQGVLIGDR LYSGVLITLE NCLLPDDKLR
    61  FTPSMSSGLD TDTETDLRVV GCELIQAAGI LLRLPQVAMA TGQVLFQRFF YTKSFVKHSM
   121  EHVSMACVHL ASKIEEAPRR IRDVINVFHR LRQLRDKKKP VPLLLDQDYV NLKNQIIKAE
   181  RRVLKELGFC VHVKHPHKII VMYLQVLECE RNQHLVQTSW NYMNDSLRTD VFVRFQPESI
   241  ACACIYLAAR TLEIPLPNRP HWFLLFGATE EEIQEICLKI LQLYARKKVD LTHLEGEVEK
   301  RKHAIEEAKA QARGLLPGGT QVLDGTSGFS PAPKLVESPK EGKGSKPSPL SVKNTKRRLE
   361  GAKKAKADSP VNGLPKGRES RSRSRSREQS YSRSPSRSAS PKRRKSDSGS TSGGSKSQSR
   421  SRSRSDSPPR QAPRSAPYKG SEIRGSRKSK DCKYPQKPHK SRSRSSSRSR SRSRERADNP
   481  GKYKKKSHYY RDQRRERSRS YERTGRRYER DHPGHSRHRR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCNL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 85 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 85 nTPM
ovary: 81 nTPM
pancreas: 80 nTPM
liver: 76 nTPM
thyroid gland: 75 nTPM
cervix: 74 nTPM

Single-cell type

adipocytes: 132 nCPM
proximal tubule cells: 130 nCPM
podocytes: 129 nCPM
cardiomyocytes: 124 nCPM
adrenal cortex cells: 120 nCPM
breast lactating cells: 109 nCPM

Immune cell

eosinophil: 7.9 nTPM
naive CD4 T-cell: 7.4 nTPM
naive B-cell: 7.3 nTPM
memory CD8 T-cell: 6.9 nTPM
gdT-cell: 6.6 nTPM
memory CD4 T-cell: 6.5 nTPM

Brain region

choroid plexus: 62 nTPM
white matter: 55 nTPM
cerebellum: 51 nTPM
cerebral cortex: 41 nTPM
pons: 41 nTPM
thalamus: 40 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.47
gnomAD pLI: 0.16
gnomAD missense Z: 0.54
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

cyclin-dependent protein serine/threonine kinase regulator activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCNL2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCNL2 as an antibody target. Whether an autoantibody or antibody against CCNL2 could matter depends on whether native CCNL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCNL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCNL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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