Seroatlas · Human Serome Atlas

FMNL3

Formin-like protein 3

Also known as: DKFZp762B245, FMNL3_HUMAN, MGC45819, WBP3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IVF7
Gene: FMNL3
Ensembl: ENSG00000161791
Chromosome: 12
Canonical length: 1028 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus,Vesicles,Plasma membrane,Cytosol

OverviewNCBI Gene

The protein encoded by this gene contains a formin homology 2 domain and has high sequence identity to the mouse Wbp3 protein. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1028 residues, UniProt reviewed canonical sequence.

>Q8IVF7|FMNL3
     1  MGNLESAEGV PGEPPSVPLL LPPGKMPMPE PCELEERFAL VLSSMNLPPD KARLLRQYDN
    61  EKKWDLICDQ ERFQVKNPPH TYIQKLQSFL DPSVTRKKFR RRVQESTKVL RELEISLRTN
   121  HIGWVREFLN DENKGLDVLV DYLSFAQCSV MFDFEGLESG DDGAFDKLRS WSRSIEDLQP
   181  PSALSAPFTN SLARSARQSV LRYSTLPGRR ALKNSRLVSQ KDDVHVCILC LRAIMNYQYG
   241  FNLVMSHPHA VNEIALSLNN KNPRTKALVL ELLAAVCLVR GGHEIILAAF DNFKEVCKEL
   301  HRFEKLMEYF RNEDSNIDFM VACMQFINIV VHSVEDMNFR VHLQYEFTKL GLEEFLQKSR
   361  HTESEKLQVQ IQAYLDNVFD VGGLLEDAET KNVALEKVEE LEEHVSHLTE KLLDLENENM
   421  MRVAELEKQL LQREKELESI KETYENTSHQ VHTLRRLIKE KEEAFQRRCH LEPNVRGLES
   481  VDSEALARVG PAELSEGMPP SDLDLLAPAP PPEEVLPLPP PPAPPLPPPP PPLPDKCPPA
   541  PPLPGAAPSV VLTVGLSAIR IKKPIKTKFR LPVFNWTALK PNQISGTVFS ELDDEKILED
   601  LDLDKFEELF KTKAQGPALD LICSKNKTAQ KAASKVTLLE ANRAKNLAIT LRKAGRSAEE
   661  ICRAIHTFDL QTLPVDFVEC LMRFLPTEAE VKLLRQYERE RQPLEELAAE DRFMLLFSKV
   721  ERLTQRMAGM AFLGNFQDNL QMLTPQLNAI IAASASVKSS QKLKQMLEII LALGNYMNSS
   781  KRGAVYGFKL QSLDLLLDTK STDRKMTLLH FIALTVKEKY PDLANFWHEL HFVEKAAAVS
   841  LENVLLDVKE LGRGMELIRR ECSIHDNSVL RNFLSTNEGK LDKLQRDAKT AEEAYNAVVR
   901  YFGESPKTTP PSVFFPVFVR FIRSYKEAEQ ENEARKKQEE VMREKQLAQE AKKLDAKTPS
   961  QRNKWQQQEL IAELRRRQAK EHRPVYEGKD GTIEDIITVL KSVPFTARTA KRGSRFFCDA
  1021  AHHDESNC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FMNL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

tonsil: 27 nTPM
lymph node: 22 nTPM
appendix: 19 nTPM
thymus: 19 nTPM
epididymis: 18 nTPM
ovary: 17 nTPM

Single-cell type

microglia: 567 nCPM
pdcs: 112 nCPM
mast cells: 98 nCPM
sertoli cells: 93 nCPM
macrophages: 87 nCPM
vascular endothelial cells: 79 nCPM

Immune cell

plasmacytoid DC: 5.1 nTPM
basophil: 3.1 nTPM
naive B-cell: 1.1 nTPM
eosinophil: 0.8 nTPM
gdT-cell: 0.8 nTPM
NK-cell: 0.6 nTPM

Brain region

medulla oblongata: 53 nTPM
thalamus: 50 nTPM
white matter: 49 nTPM
spinal cord: 45 nTPM
pons: 45 nTPM
midbrain: 38 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.36
gnomAD pLI: 0.47
gnomAD missense Z: 2.2
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FMNL3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SRGAP2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FMNL3 as an antibody target. Whether an autoantibody or antibody against FMNL3 could matter depends on whether native FMNL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FMNL3 is annotated at the cell surface, where native FMNL3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FMNL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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