SLIT-ROBO Rho GTPase-activating
IPR051627
Definition
The SLIT-ROBO Rho GTPase-activating protein family is involved in neuronal morphogenesis, migration, and synapse maturation, particularly in the cerebral cortex. Members of the family act as GTPase-activating proteins (GAPs) for RAC1, CDC42, and potentially other small GTPases, influencing actin dynamics and cell migration. They play roles in regulating synapse density and maturation in cortical neurons, with some members also affecting cell migration in non-neuronal cells. The family includes a human-specific member that modifies cortical connectivity by inhibiting ancestral paralog functions, leading to increased synaptic density and maturation. Members share an F-BAR domain that mediates oligomerization, membrane binding, and induction of plasma membrane protrusions. Some members also interact with postsynaptic scaffolding proteins, contributing to synapse development. The family's activity is modulated by heterodimerization and proteasome-dependent degradation, influencing synaptic and cortical circuit connectivity.
6 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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