Seroatlas · Human Serome Atlas

IFNGR1

Interferon gamma receptor 1

Also known as: CD119, IFNGR, INGR1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P15260
Gene
IFNGR1
Ensembl
ENSG00000027697
Chromosome
6
Canonical length
489 aa
Protein class
CD markers, Disease related genes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Plasma membrane

OverviewNCBI Gene

This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

489 residues, UniProt reviewed canonical sequence.

>P15260|IFNGR1
     1  MALLFLLPLV MQGVSRAEMG TADLGPSSVP TPTNVTIESY NMNPIVYWEY QIMPQVPVFT
    61  VEVKNYGVKN SEWIDACINI SHHYCNISDH VGDPSNSLWV RVKARVGQKE SAYAKSEEFA
   121  VCRDGKIGPP KLDIRKEEKQ IMIDIFHPSV FVNGDEQEVD YDPETTCYIR VYNVYVRMNG
   181  SEIQYKILTQ KEDDCDEIQC QLAIPVSSLN SQYCVSAEGV LHVWGVTTEK SKEVCITIFN
   241  SSIKGSLWIP VVAALLLFLV LSLVFICFYI KKINPLKEKS IILPKSLISV VRSATLETKP
   301  ESKYVSLITS YQPFSLEKEV VCEEPLSPAT VPGMHTEDNP GKVEHTEELS SITEVVTTEE
   361  NIPDVVPGSH LTPIERESSS PLSSNQSEPG SIALNSYHSR NCSESDHSRN GFDTDSSCLE
   421  SHSSLSDSEF PPNNKGEIKT EGQELITVIK APTSFGYDKP HVLVDLLVDD SGKESLIGYR
   481  PTEDSKEFS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IFNGR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
154 nTPM

Expression across tissuesHPA

Tissue

  • lung: 154 nTPM
  • spleen: 153 nTPM
  • adipose tissue: 141 nTPM
  • lymph node: 129 nTPM
  • tonsil: 124 nTPM
  • bone marrow: 121 nTPM

Single-cell type

  • neutrophils: 1,083 nCPM
  • microglia: 674 nCPM
  • kupffer cells: 521 nCPM
  • cdc: 375 nCPM
  • monocytes: 360 nCPM
  • syncytiotrophoblasts: 346 nCPM

Immune cell

  • neutrophil: 665 nTPM
  • total PBMC: 449 nTPM
  • classical monocyte: 448 nTPM
  • intermediate monocyte: 438 nTPM
  • non-classical monocyte: 332 nTPM
  • eosinophil: 314 nTPM

Brain region

  • white matter: 105 nTPM
  • medulla oblongata: 85 nTPM
  • spinal cord: 70 nTPM
  • pons: 66 nTPM
  • cerebellum: 61 nTPM
  • thalamus: 55 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IFNGR1.

Disease | AllUniProt

Conditions IFNGR1 is implicated in, by any mechanism.

Disease | GeneticClinVar

36 pathogenic / likely-pathogenic of 439 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Immunodeficiency 27A
  • Disseminated atypical mycobacterial infection
  • Autosomal dominant mendelian susceptibility to mycobacterial diseases due to partial IFNgammaR1 deficiency
  • Mycobacterium tuberculosis, susceptibility to
  • IFN-gamma receptor 1 deficiency

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.7
gnomAD pLI
0.02
gnomAD missense Z
0.31
DepMap mean gene effect
0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IFNGR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IFNGR1 as an antibody target. Whether an autoantibody or antibody against IFNGR1 could matter depends on whether native IFNGR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IFNGR1 is annotated at the cell surface, where native IFNGR1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IFNGR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IFNGR1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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