Centrosomal Protein 152/SHC-Transforming Protein

Definition

The CEP152 family is involved in centrosome duplication and centriole formation. Members act as molecular scaffolds, facilitating interactions between key molecules such as PLK4 and CENPJ. They are essential for recruiting CDK2, which is required for centriole duplication. The family also plays a significant role in deuterosome-mediated centriole amplification in multiciliated cells, enabling the generation of over 100 centrioles. Overexpression of CEP152 family members can induce centriole amplification. In contrast, the SHC family members function as signaling adapters, coupling activated growth factor receptors to various signaling pathways. They are involved in pathways initiated by receptors like KIT and TEK/TIE2, influencing processes such as endothelial cell migration, sprouting angiogenesis, and neuron signaling. Specific members also activate Ras-dependent and independent pathways and contribute to stress response signaling.

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• CEP152
• SHC1
• SHC2
• SHC3
• SHC4