Seroatlas · Human Serome Atlas

SH2B2

SH2B adapter protein 2

Also known as: APS, SH2B2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O14492
Gene
SH2B2
Ensembl
ENSG00000160999
Chromosome
7
Canonical length
632 aa
Protein class
Predicted intracellular proteins
Subcellular location
Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt's lymphoma cell lines, it is tyrosine-phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to the Shc/Grb2 pathway. [provided by RefSeq, Jun 2009]

Canonical amino-acid sequenceUniProt

632 residues, UniProt reviewed canonical sequence.

>O14492|SH2B2
     1  MNGAGPGPAA AAPVPVPVPV PDWRQFCELH AQAAAVDFAH KFCRFLRDNP AYDTPDAGAS
    61  FSRHFAANFL DVFGEEVRRV LVAGPTTRGA AVSAEAMEPE LADTSALKAA PYGHSRSSED
   121  VSTHAATKAR VRKGFSLRNM SLCVVDGVRD MWHRRASPEP DAAAAPRTAE PRDKWTRRLR
   181  LSRTLAAKVE LVDIQREGAL RFMVADDAAA GSGGSAQWQK CRLLLRRAVA EERFRLEFFV
   241  PPKASRPKVS IPLSAIIEVR TTMPLEMPEK DNTFVLKVEN GAEYILETID SLQKHSWVAD
   301  IQGCVDPGDS EEDTELSCTR GGCLASRVAS CSCELLTDAV DLPRPPETTA VGAVVTAPHS
   361  RGRDAVRESL IHVPLETFLQ TLESPGGSGS DSNNTGEQGA ETDPEAEPEL ELSDYPWFHG
   421  TLSRVKAAQL VLAGGPRNHG LFVIRQSETR PGEYVLTFNF QGKAKHLRLS LNGHGQCHVQ
   481  HLWFQSVLDM LRHFHTHPIP LESGGSADIT LRSYVRAQDP PPEPGPTPPA APASPACWSD
   541  SPGQHYFSSL AAAACPPASP SDAAGASSSS ASSSSAASGP APPRPVEGQL SARSRSNSAE
   601  RLLEAVAATA AEEPPEAAPG RARAVENQYS FY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SH2B2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
33 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 33 nTPM
  • spleen: 13 nTPM
  • tongue: 13 nTPM
  • lymph node: 9.9 nTPM
  • cerebellum: 8.4 nTPM
  • hypothalamus: 8 nTPM

Single-cell type

  • neutrophils: 205 nCPM
  • extravillous trophoblasts: 105 nCPM
  • syncytiotrophoblasts: 82 nCPM
  • b-cells: 39 nCPM
  • plasma cells: 37 nCPM
  • migrating cytotrophoblasts: 31 nCPM

Immune cell

  • naive B-cell: 2.9 nTPM
  • intermediate monocyte: 1.6 nTPM
  • neutrophil: 1.6 nTPM
  • non-classical monocyte: 0.6 nTPM
  • memory B-cell: 0.4 nTPM
  • classical monocyte: 0.3 nTPM

Brain region

  • midbrain: 20 nTPM
  • hypothalamus: 19 nTPM
  • medulla oblongata: 18 nTPM
  • thalamus: 18 nTPM
  • pons: 13 nTPM
  • spinal cord: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.89
gnomAD pLI
0
gnomAD missense Z
1.84

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SH2B2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SH2B2 as an antibody target. Whether an autoantibody or antibody against SH2B2 could matter depends on whether native SH2B2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SH2B2 is annotated at the cell surface, where native SH2B2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SH2B2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SH2B2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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