Seroatlas · Human Serome Atlas

ARC

Activity-regulated cytoskeleton-associated protein

Also known as: ARC_HUMAN, Arg3.1, KIAA0278

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7LC44
Gene
ARC
Ensembl
ENSG00000198576
Chromosome
8
Canonical length
396 aa
Protein class
Predicted intracellular proteins
Subcellular location
Vesicles,Microtubules
Quaternary structure
Homooligomer

OverviewNCBI Gene

Enables mRNA binding activity and structural molecule activity. Involved in cell migration; cytoskeleton organization; and regulation of cell morphogenesis. Located in cytoplasm and plasma membrane. Part of virus-like capsid. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

396 residues, UniProt reviewed canonical sequence.

>Q7LC44|ARC
     1  MELDHRTSGG LHAYPGPRGG QVAKPNVILQ IGKCRAEMLE HVRRTHRHLL AEVSKQVERE
    61  LKGLHRSVGK LESNLDGYVP TSDSQRWKKS IKACLCRCQE TIANLERWVK REMHVWREVF
   121  YRLERWADRL ESTGGKYPVG SESARHTVSV GVGGPESYCH EADGYDYTVS PYAITPPPAA
   181  GELPGQEPAE AQQYQPWVPG EDGQPSPGVD TQIFEDPREF LSHLEEYLRQ VGGSEEYWLS
   241  QIQNHMNGPA KKWWEFKQGS VKNWVEFKKE FLQYSEGTLS REAIQRELDL PQKQGEPLDQ
   301  FLWRKRDLYQ TLYVDADEEE IIQYVVGTLQ PKLKRFLRHP LPKTLEQLIQ RGMEVQDDLE
   361  QAAEPAGPHL PVEDEAETLT PAPNSESVAS DRTQPE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
68 nTPM

Expression across tissuesHPA

Tissue

  • pituitary gland: 68 nTPM
  • hippocampal formation: 36 nTPM
  • hypothalamus: 25 nTPM
  • cerebral cortex: 23 nTPM
  • basal ganglia: 17 nTPM
  • amygdala: 16 nTPM

Single-cell type

  • pituicytes/fscs: 302 nCPM
  • epididymal basal cells: 288 nCPM
  • epididymal principal cells: 136 nCPM
  • breast lactating cells: 99 nCPM
  • breast myoepithelial cells: 89 nCPM
  • neuroendocrine cells: 83 nCPM

Immune cell

  • gdT-cell: 0.2 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 242 nTPM
  • hippocampal formation: 71 nTPM
  • hypothalamus: 27 nTPM
  • white matter: 23 nTPM
  • basal ganglia: 13 nTPM
  • amygdala: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.49
gnomAD pLI
0.59
gnomAD missense Z
2.6
DepMap mean gene effect
0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Activity-regulated cytoskeleton-associated protein
  • Activity-regulated cytoskeleton-associated protein, C-lobe
  • Activity-regulated cytoskeleton-associated protein, N-terminal domain
  • Activity-regulated cytoskeleton-associated protein, N-lobe
  • Arc C-lobe
  • Arc MA domain
  • Activity-regulated cytoskeleton-associated protein, capsid domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARC in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARC as an antibody target. Whether an autoantibody or antibody against ARC could matter depends on whether native ARC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARC is annotated at the cell surface, where native ARC is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ARC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ARC. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...