ANXA6

Protein identityUniProt · HPA

UniProt accession

P08133

Gene

ANXA6

Ensembl

ENSG00000197043

Chromosome

5

Canonical length

673 aa

Protein class

Plasma proteins, Predicted intracellular proteins, Transporters

Subcellular location

Basal body,Cytosol

OverviewNCBI Gene

Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. The annexin VI gene is approximately 60 kbp long and contains 26 exons. It encodes a protein of about 68 kDa that consists of eight 68-amino acid repeats separated by linking sequences of variable lengths. It is highly similar to human annexins I and II sequences, each of which contain four such repeats. Annexin VI has been implicated in mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2010]

Canonical amino-acid sequenceUniProt

673 residues, UniProt reviewed canonical sequence.

>P08133|ANXA6
     1  MAKPAQGAKY RGSIHDFPGF DPNQDAEALY TAMKGFGSDK EAILDIITSR SNRQRQEVCQ
    61  SYKSLYGKDL IADLKYELTG KFERLIVGLM RPPAYCDAKE IKDAISGIGT DEKCLIEILA
   121  SRTNEQMHQL VAAYKDAYER DLEADIIGDT SGHFQKMLVV LLQGTREEDD VVSEDLVQQD
   181  VQDLYEAGEL KWGTDEAQFI YILGNRSKQH LRLVFDEYLK TTGKPIEASI RGELSGDFEK
   241  LMLAVVKCIR STPEYFAERL FKAMKGLGTR DNTLIRIMVS RSELDMLDIR EIFRTKYEKS
   301  LYSMIKNDTS GEYKKTLLKL SGGDDDAAGQ FFPEAAQVAY QMWELSAVAR VELKGTVRPA
   361  NDFNPDADAK ALRKAMKGLG TDEDTIIDII THRSNVQRQQ IRQTFKSHFG RDLMTDLKSE
   421  ISGDLARLIL GLMMPPAHYD AKQLKKAMEG AGTDEKALIE ILATRTNAEI RAINEAYKED
   481  YHKSLEDALS SDTSGHFRRI LISLATGHRE EGGENLDQAR EDAQVAAEIL EIADTPSGDK
   541  TSLETRFMTI LCTRSYPHLR RVFQEFIKMT NYDVEHTIKK EMSGDVRDAF VAIVQSVKNK
   601  PLFFADKLYK SMKGAGTDEK TLTRIMVSRS EIDLLNIRRE FIEKYDKSLH QAIEGDTSGD
   661  FLKALLALCG GED

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANXA6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.23

Highest tissue expression

315 nTPM

Expression across tissuesHPA

ReferencesPubMed · IEDB

Publications for ANXA6 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.71

gnomAD pLI

0

gnomAD missense Z

0.64

DepMap mean gene effect

0.19

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• apoptotic signaling pathway
• calcium ion transport
• mitochondrial calcium ion homeostasis
• monoatomic ion transmembrane transport
• regulation of muscle contraction
• negative regulation of sequestering of calcium ion

Molecular functions

• calcium ion binding
• calcium-dependent phospholipid binding
• calcium-dependent protein binding
• cholesterol binding
• GTP binding
• identical protein binding
• ligand-gated monoatomic ion channel activity
• lipid binding
• phosphatidylserine binding

Cellular components

• cytoplasm
• extracellular exosome
• extracellular matrix
• focal adhesion
• late endosome membrane
• lysosomal membrane
• melanosome
• membrane
• mitochondrion
• nucleus
• perinuclear region of cytoplasm
• plasma membrane
• vesicle membrane

Protein domainsUniProt · Pfam · InterPro

• Annexin
• Annexin repeat, conserved site
• Annexin repeat
• Annexin superfamily
• Annexin
• Annexin A6

KeywordsUniProt

• Acetylation
• Annexin
• Calcium
• Calcium/phospholipid-binding
• Cytoplasm
• Phosphoprotein
• Repeat

InteractionsUniProt · HPA

Protein binding partners of ANXA6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• S100A8
• S100A9