ANXA11

Protein identityUniProt · HPA

UniProt accession

P50995

Gene

ANXA11

Ensembl

ENSG00000122359

Chromosome

10

Canonical length

505 aa

Protein class

Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters

Subcellular location

Nucleoplasm,Vesicles,Cytosol

OverviewNCBI Gene

This gene encodes a member of the annexin family, a group of calcium-dependent phospholipid-binding proteins. Annexins have unique N-terminal domains and conserved C-terminal domains, which contain calcium-dependent phospholipid-binding sites. The encoded protein is a 56-kD antigen recognized by sera from patients with various autoimmune diseases. Several transcript variants encoding two different isoforms have been identified. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

505 residues, UniProt reviewed canonical sequence.

>P50995|ANXA11
     1  MSYPGYPPPP GGYPPAAPGG GPWGGAAYPP PPSMPPIGLD NVATYAGQFN QDYLSGMAAN
    61  MSGTFGGANM PNLYPGAPGA GYPPVPPGGF GQPPSAQQPV PPYGMYPPPG GNPPSRMPSY
   121  PPYPGAPVPG QPMPPPGQQP PGAYPGQPPV TYPGQPPVPL PGQQQPVPSY PGYPGSGTVT
   181  PAVPPTQFGS RGTITDAPGF DPLRDAEVLR KAMKGFGTDE QAIIDCLGSR SNKQRQQILL
   241  SFKTAYGKDL IKDLKSELSG NFEKTILALM KTPVLFDIYE IKEAIKGVGT DEACLIEILA
   301  SRSNEHIREL NRAYKAEFKK TLEEAIRSDT SGHFQRLLIS LSQGNRDEST NVDMSLAQRD
   361  AQELYAAGEN RLGTDESKFN AVLCSRSRAH LVAVFNEYQR MTGRDIEKSI CREMSGDLEE
   421  GMLAVVKCLK NTPAFFAERL NKAMRGAGTK DRTLIRIMVS RSETDLLDIR SEYKRMYGKS
   481  LYHDISGDTS GDYRKILLKI CGGND

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANXA11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.41

Highest tissue expression

221 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ANXA11.

Disease | AllUniProt

Conditions ANXA11 is implicated in, by any mechanism.

• Amyotrophic lateral sclerosis 23 (ALS23) MIM:617839
• Inclusion body myopathy and brain white matter abnormalities (IBMWMA) MIM:619733

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 470 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Amyotrophic lateral sclerosis type 23
• ANXA11-related disorder
• Amyotrophic lateral sclerosis
• Inclusion body myopathy and brain white matter abnormalities
• Oculopharyngeal muscular dystrophy 1

ReferencesPubMed · IEDB

Publications for ANXA11 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.98

gnomAD pLI

0

gnomAD missense Z

-0.25

DepMap mean gene effect

0.1

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cytokinetic process
• phagocytosis
• response to calcium ion

Molecular functions

• calcium ion binding
• calcium-dependent phospholipid binding
• calcium-dependent protein binding
• MHC class II protein complex binding
• phosphatidylethanolamine binding
• phosphatidylserine binding
• RNA binding
• S100 protein binding

Cellular components

• azurophil granule
• cytoplasm
• cytosol
• extracellular exosome
• extracellular matrix
• melanosome
• membrane
• midbody
• nuclear envelope
• nucleoplasm
• nucleus
• phagocytic vesicle
• plasma membrane
• specific granule
• spindle
• vesicle membrane

Protein domainsUniProt · Pfam · InterPro

• Annexin
• Annexin repeat, conserved site
• Annexin repeat
• Annexin superfamily
• Annexin
• Annexin A11

KeywordsUniProt

• Acetylation
• Amyotrophic lateral sclerosis
• Annexin
• Calcium
• Calcium/phospholipid-binding
• Cell cycle
• Cell division
• Cytoplasm
• Cytoskeleton
• Neurodegeneration
• Nucleus
• Repeat

InteractionsUniProt · HPA

Protein binding partners of ANXA11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PDCD6
• S100A6