Seroatlas · Human Serome Atlas

ANXA2

Annexin A2

Also known as: ANX2, ANX2L4, ANXA2_HUMAN, CAL1H, LIP2, LPC2D

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P07355
Gene
ANXA2
Ensembl
ENSG00000182718
Chromosome
15
Canonical length
339 aa
Protein class
Cancer-related genes, Disease related genes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins, Transporters
Subcellular location
Plasma membrane,Cytosol
Secretome location
Secreted to blood

OverviewNCBI Gene

This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. Annexin A2 expression has been found to correlate with resistance to treatment against various cancer forms. [provided by RefSeq, Dec 2019]

Canonical amino-acid sequenceUniProt

339 residues, UniProt reviewed canonical sequence.

>P07355|ANXA2
     1  MSTVHEILCK LSLEGDHSTP PSAYGSVKAY TNFDAERDAL NIETAIKTKG VDEVTIVNIL
    61  TNRSNAQRQD IAFAYQRRTK KELASALKSA LSGHLETVIL GLLKTPAQYD ASELKASMKG
   121  LGTDEDSLIE IICSRTNQEL QEINRVYKEM YKTDLEKDII SDTSGDFRKL MVALAKGRRA
   181  EDGSVIDYEL IDQDARDLYD AGVKRKGTDV PKWISIMTER SVPHLQKVFD RYKSYSPYDM
   241  LESIRKEVKG DLENAFLNLV QCIQNKPLYF ADRLYDSMKG KGTRDKVLIR IMVSRSEVDM
   301  LKIRSEFKRK YGKSLYYYIQ QDTKGDYQKA LLYLCGGDD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANXA2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
1,963 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 1,963 nTPM
  • vagina: 1,143 nTPM
  • cervix: 1,111 nTPM
  • skin: 1,034 nTPM
  • adipose tissue: 854 nTPM
  • lung: 827 nTPM

Single-cell type

  • esophageal apical cells: 13,656 nCPM
  • esophageal suprabasal cells: 5,849 nCPM
  • ocular epithelial cells: 3,817 nCPM
  • extravillous trophoblasts: 3,721 nCPM
  • suprabasal keratinocytes: 2,907 nCPM
  • migrating cytotrophoblasts: 2,843 nCPM

Immune cell

  • basophil: 4,446 nTPM
  • myeloid DC: 4,023 nTPM
  • total PBMC: 3,755 nTPM
  • classical monocyte: 2,767 nTPM
  • non-classical monocyte: 2,699 nTPM
  • intermediate monocyte: 2,405 nTPM

Brain region

  • thalamus: 196 nTPM
  • choroid plexus: 130 nTPM
  • medulla oblongata: 122 nTPM
  • pons: 110 nTPM
  • midbrain: 108 nTPM
  • hypothalamus: 99 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ANXA2.

Disease | ImmuneIEDB

Conditions an epitope on ANXA2 was assayed in.

Disease | AutoantibodyPubMed

Conditions in which antibodies against ANXA2 are reported. Each links to that disease's full target list.

ReferencesPubMed · IEDB

Publications for ANXA2 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Reference: AutoantibodyPubMed

24 publications

Show 19 more

Reference: T cellIEDB

1 publication

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.81
gnomAD pLI
0
gnomAD missense Z
0.28
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ANXA2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANXA2 as an antibody target. Whether an autoantibody or antibody against ANXA2 could matter depends on whether native ANXA2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANXA2 is annotated at the cell surface, where native ANXA2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ANXA2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ANXA2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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