ZNF696
Zinc finger protein 696
Also known as: FLJ14129, ZN696_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9H7X3
- Gene
- ZNF696
- Ensembl
- ENSG00000185730
- Chromosome
- 8
- Canonical length
- 374 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm,Nucleoli
OverviewNCBI Gene
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
374 residues, UniProt reviewed canonical sequence.
>Q9H7X3|ZNF696
1 MEPGGEPTGA KESSTLMESL AAVKAAFLAQ APSGSRSAEV QAAQSTEPAA EAGAPEGEGH
61 RGGPPRALGS LGLCENQEAR ERPGGSPRGP VTSEKTGGQS GLESDVPPNA GPGAEGGGSW
121 KGRPFPCGAC GRSFKCSSDA AKHRSIHSGE KPYECSDCGK AFIHSSHVVR HQRAHSGERP
181 YACAECGKAF GQSFNLLRHQ RVHTGEKPYA CADCGKAFGQ RSDAAKHRRT HTGERLYACG
241 ECGKRFLHSS NVVRHRRTHH GENPYECREC GQAFSQSSNL LQHQRVHTGE RPFACQDCGR
301 AFSRSSFLRE HRRIHTGEKP HQCGHCGRAF RALSGFFRHQ RLHTGEKPFR CTECGRAFRL
361 SFHLIQHRRV HGAELocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZNF696 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.48
- Highest tissue expression
- 6.2 nTPM
Expression across tissuesHPA
Tissue
- skin: 6.2 nTPM
- cerebellum: 5.8 nTPM
- duodenum: 5.7 nTPM
- cerebral cortex: 5.6 nTPM
- salivary gland: 5.4 nTPM
- hypothalamus: 4.9 nTPM
Single-cell type
- cardiomyocytes: 15 nCPM
- erythrocyte progenitors: 12 nCPM
- differentiating spermatogonia: 11 nCPM
- retinal amacrine cells: 9.2 nCPM
- myonuclei: 8.7 nCPM
- myosatellite cells: 8.6 nCPM
Immune cell
- naive CD4 T-cell: 3.9 nTPM
- plasmacytoid DC: 3.8 nTPM
- naive CD8 T-cell: 3.5 nTPM
- NK-cell: 3.5 nTPM
- naive B-cell: 3.2 nTPM
- memory CD8 T-cell: 3.1 nTPM
Brain region
- cerebral cortex: 33 nTPM
- cerebellum: 33 nTPM
- pons: 32 nTPM
- medulla oblongata: 31 nTPM
- white matter: 30 nTPM
- basal ganglia: 29 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.91
- gnomAD pLI
- 0.21
- gnomAD missense Z
- 0.18
- DepMap mean gene effect
- -0.09
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 18% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
- DNA-binding transcription factor activity, RNA polymerase II-specific
- RNA polymerase II transcription regulatory region sequence-specific DNA binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of ZNF696 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZNF696 as an antibody target. Whether an autoantibody or antibody against ZNF696 could matter depends on whether native ZNF696 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZNF696 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZNF696 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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