Seroatlas · Human Serome Atlas

ZNF319

Zinc finger protein 319

Also known as: KIAA1388, Zfp319, ZN319_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9P2F9
Gene
ZNF319
Ensembl
ENSG00000166188
Chromosome
16
Canonical length
582 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

582 residues, UniProt reviewed canonical sequence.

>Q9P2F9|ZNF319
     1  MSESWQQPPQ TQPQQPQPPQ PQHHAEPPPA LAEHTLPPGT AENPLGCAVY GILLQPDPGL
    61  QPPQHAPLQA AGEPGPKCGV CGHDLAHLSS PHEHQCLAGH DRSFQCTQCL KIFHQATDLL
   121  EHQCVQAEQK PFVCGVCKMG FSLLTSLAQH HSSHSGLVKC SICEKTYKPA EAAEPATTAA
   181  PSLPAAPAPS TVTPAEQADK PYSCPICQKP FKHLSELSRH ERIHTGEKPY KCTLCDKSFS
   241  QSSHLVHHKR THSSERPYKC AVCEKTFKHR SHLVRHMYAH SGEHHLFRCN VCELHFKESS
   301  ELLQHPCTPS GERPFRCGEC QKAFKRPSDL RQHERTHSAE RPFKCDLCPM GFKQQYALMR
   361  HRRTHKTEEP FKCGLCEKGF GQPSHLLYHQ HVHTLETLFK CPVCQKGFDQ SAELLRHKCL
   421  PGAAERPFKC PVCNKAYKRA SALQKHQLAH CAAAEKPLRC TLCERRFFSS SEFVQHRCDP
   481  AREKPLKCPD CEKRFKYASD LQRHRRVHTG EKPYKCPNCD KAFKQREHLN KHQGVHAREQ
   541  QFKCVWCGER FLDVALLQEH SAQHSAAAAA AEGAYQVAAC LP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF319 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
11 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 11 nTPM
  • parathyroid gland: 5.8 nTPM
  • spleen: 5.8 nTPM
  • endometrium: 5.2 nTPM
  • thyroid gland: 5.1 nTPM
  • cerebellum: 5 nTPM

Single-cell type

  • adrenal medulla cells: 21 nCPM
  • neutrophils: 20 nCPM
  • kupffer cells: 11 nCPM
  • neutrophil progenitors: 8 nCPM
  • monocyte progenitors: 7.3 nCPM
  • medullary thymic epithelial cells: 7.2 nCPM

Immune cell

  • eosinophil: 3.4 nTPM
  • gdT-cell: 2.1 nTPM
  • neutrophil: 1.8 nTPM
  • memory CD8 T-cell: 1.4 nTPM
  • total PBMC: 1.4 nTPM
  • MAIT T-cell: 1.2 nTPM

Brain region

  • cerebellum: 14 nTPM
  • cerebral cortex: 14 nTPM
  • medulla oblongata: 14 nTPM
  • thalamus: 14 nTPM
  • pons: 14 nTPM
  • midbrain: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.25
gnomAD pLI
0.99
gnomAD missense Z
2.84
DepMap mean gene effect
-0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF319 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF319 as an antibody target. Whether an autoantibody or antibody against ZNF319 could matter depends on whether native ZNF319 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF319 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF319 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF319. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...