Seroatlas · Human Serome Atlas

ZNF275

Zinc finger protein 275

Also known as: ZN275_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NSD4
Gene: ZNF275
Ensembl: ENSG00000063587
Chromosome: X
Canonical length: 429 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoli

OverviewNCBI Gene

This gene encodes a zinc finger protein that appears to be conserved in eutheria. Its function has not yet been established. [provided by RefSeq, Jul 2010]

Canonical amino-acid sequenceUniProt

429 residues, UniProt reviewed canonical sequence.

>Q9NSD4|ZNF275
     1  MMSHPCVSLL GVPVLNPALV PHLAQGQVLL VSDPSPNTDP AKYSESTSAT RHQMKGEDAQ
    61  PQEMASTSFP RASGPSPEFR QHGDSDGKRG SPQNLPIEHH FACKECGDTF RLKVLLVQHQ
   121  RVHSEEKGWE CGDCGKVFRG VAEFNEHRKS HVAAEPQPGP SRALENAAEK REQMEREAKP
   181  FECEECGKRF KKNAGLSQHL RVHSREKPFD CEECGRSFKV NTHLFRHQKL HTSEKPFACK
   241  ACSRDFLDRQ ELLKHQRMHT GHLPFDCDDC GKSFRGVNGL AEHQRIHSGA KPYGCPHCGK
   301  LFRRSSELTK HRRIHTGEKP YACGQCGKAF RQSSSLLEHA RIHSGERPYA CGECGKAFRG
   361  PSDLIKHRRI HSGLKPYECD KCGKAFRRSS GLSRHRRIHS GARRCECSQC GRVFKRRSAL
   421  QKHQPTHHE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF275 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 68 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 68 nTPM
ovary: 40 nTPM
parathyroid gland: 30 nTPM
epididymis: 17 nTPM
seminal vesicle: 14 nTPM
liver: 13 nTPM

Single-cell type

adrenal cortex cells: 190 nCPM
granulosa cells: 56 nCPM
adrenal medulla cells: 53 nCPM
sertoli cells: 47 nCPM
gonadotrophs: 40 nCPM
plasma cells: 40 nCPM

Immune cell

T-reg: 2.4 nTPM
naive CD4 T-cell: 2.1 nTPM
memory B-cell: 2 nTPM
naive B-cell: 2 nTPM
MAIT T-cell: 1.9 nTPM
naive CD8 T-cell: 1.8 nTPM

Brain region

hypothalamus: 21 nTPM
white matter: 20 nTPM
spinal cord: 19 nTPM
medulla oblongata: 18 nTPM
pons: 17 nTPM
midbrain: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.23
gnomAD pLI: 0
gnomAD missense Z: 0.97

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF275 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

RNF4

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF275 as an antibody target. Whether an autoantibody or antibody against ZNF275 could matter depends on whether native ZNF275 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF275 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF275 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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