Seroatlas · Human Serome Atlas

UBE2W

Ubiquitin-conjugating enzyme E2 W

Also known as: FLJ11011, UBC-16, UBE2W_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96B02
Gene: UBE2W
Ensembl: ENSG00000104343
Chromosome: 8
Canonical length: 151 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoli
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a nuclear-localized ubiquitin-conjugating enzyme (E2) that, along with ubiquitin-activating (E1) and ligating (E3) enzymes, coordinates the addition of a ubiquitin moiety to existing proteins. The encoded protein promotes the ubiquitination of Fanconi anemia complementation group proteins and may be important in the repair of DNA damage. There is a pseudogene for this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Canonical amino-acid sequenceUniProt

151 residues, UniProt reviewed canonical sequence.

>Q96B02|UBE2W
     1  MASMQKRLQK ELLALQNDPP PGMTLNEKSV QNSITQWIVD MEGAPGTLYE GEKFQLLFKF
    61  SSRYPFDSPQ VMFTGENIPV HPHVYSNGHI CLSILTEDWS PALSVQSVCL SIISMLSSCK
   121  EKRRPPDNSF YVRTCNKNPK KTKWWYHDDT C

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBE2W can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

liver: 12 nTPM
bone marrow: 11 nTPM
kidney: 10 nTPM
retina: 9.6 nTPM
tongue: 9.3 nTPM
urinary bladder: 9 nTPM

Single-cell type

microglia: 332 nCPM
choroid plexus epithelial cells: 151 nCPM
brain excitatory neurons: 129 nCPM
brain inhibitory neurons: 105 nCPM
other brain neurons: 105 nCPM
oligodendrocyte progenitor cells: 95 nCPM

Immune cell

neutrophil: 33 nTPM
basophil: 24 nTPM
eosinophil: 18 nTPM
non-classical monocyte: 15 nTPM
classical monocyte: 13 nTPM
intermediate monocyte: 13 nTPM

Brain region

cerebral cortex: 36 nTPM
cerebellum: 35 nTPM
hippocampal formation: 33 nTPM
basal ganglia: 33 nTPM
white matter: 30 nTPM
thalamus: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.7
gnomAD pLI: 0.09
gnomAD missense Z: 1.81
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UBE2W in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBE2W as an antibody target. Whether an autoantibody or antibody against UBE2W could matter depends on whether native UBE2W is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBE2W is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBE2W as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...