Seroatlas · Human Serome Atlas

RGP1

RAB6A-GEF complex partner protein 2

Also known as: KIAA0258, RGP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q92546
Gene
RGP1
Ensembl
ENSG00000107185
Chromosome
9
Canonical length
391 aa
Protein class
Predicted intracellular proteins
Subcellular location
Plasma membrane,Cytosol

OverviewNCBI Gene

Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in negative regulation of protein catabolic process; positive regulation of GTPase activity; and retrograde transport, endosome to Golgi. Located in cytosol and plasma membrane. Part of Ric1-Rgp1 guanyl-nucleotide exchange factor complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

391 residues, UniProt reviewed canonical sequence.

>Q92546|RGP1
     1  MIEVVAELSR GPVFLAGEAL ECVVTVTNPL PPTATSASSE ALAWASAQIH CQFHASESRV
    61  ALPPPDSSQP DVQPDSQTVF LPHRGERGQC ILSTPPKILF CDLRLDPGES KSYSYSEVLP
   121  IEGPPSFRGQ SVKYVYKLTI GCQRVNSPIT LLRVPLRVLV LTGLQDVRFP QDEAVAPSSP
   181  FLEEDEGGKK DSWLAELAGE RLMAATSCRS LHLYNISDGR GKVGTFGIFK SVYRLGEDVV
   241  GTLNLGEGTV ACLQFSVSLQ TEERVQPEYQ RRRGAGGVPS VSHVTHARHQ ESCLHTTRTS
   301  FSLPIPLSST PGFCTAIVSL KWRLHFEFVT SREPGLVLLP PVEQPEPTTW TGPEQVPVDT
   361  FSWDLPIKVL PTSPTLASYA APGPSTSTIT I

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RGP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
18 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 18 nTPM
  • tongue: 17 nTPM
  • skeletal muscle: 16 nTPM
  • rectum: 13 nTPM
  • colon: 12 nTPM
  • heart muscle: 12 nTPM

Single-cell type

  • late spermatids: 58 nCPM
  • colonocytes: 41 nCPM
  • enterocytes: 36 nCPM
  • lactotrophs: 36 nCPM
  • neuroendocrine cells: 35 nCPM
  • tuft cells: 35 nCPM

Immune cell

  • basophil: 1.1 nTPM
  • NK-cell: 1.1 nTPM
  • MAIT T-cell: 1 nTPM
  • naive B-cell: 1 nTPM
  • memory B-cell: 0.8 nTPM
  • memory CD8 T-cell: 0.8 nTPM

Brain region

  • hypothalamus: 26 nTPM
  • amygdala: 24 nTPM
  • cerebral cortex: 24 nTPM
  • thalamus: 24 nTPM
  • basal ganglia: 23 nTPM
  • midbrain: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.13
gnomAD pLI
0
gnomAD missense Z
0.72
DepMap mean gene effect
-0.52
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Reduced growth phenotype protein 1
  • Rgp1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RGP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RGP1 as an antibody target. Whether an autoantibody or antibody against RGP1 could matter depends on whether native RGP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RGP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RGP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RGP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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