Seroatlas · Human Serome Atlas

BICDL1

BICD family-like cargo adapter 1

Also known as: BICDR-1, BICL1_HUMAN, CCDC64, FLJ26450

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6ZP65
Gene
BICDL1
Ensembl
ENSG00000135127
Chromosome
12
Canonical length
573 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Vesicles,Cytosol

OverviewNCBI Gene

Predicted to enable dynactin binding activity and small GTPase binding activity. Predicted to be involved in Golgi to secretory granule transport; neuron projection development; and vesicle transport along microtubule. Predicted to be located in centrosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

573 residues, UniProt reviewed canonical sequence.

>Q6ZP65|BICDL1
     1  MSAFCLGLVG RASAPAEPDS ACCMELPAAA GDAVRSPAAA AALIFPGGSG ELELALEEEL
    61  ALLAAGERPS DPGEHPQAEP GSLAEGAGPQ PPPSQDPELL SVIRQKEKDL VLAARLGKAL
   121  LERNQDMSRQ YEQMHKELTD KLEHLEQEKH ELRRRFENRE GEWEGRVSEL ESDVKQLQDE
   181  LERQQIHLRE ADREKSRAVQ ELSEQNQRLL DQLSRASEVE RQLSMQVHAL REDFREKNSS
   241  TNQHIIRLES LQAEIKMLSD RKRELEHRLS ATLEENDLLQ GTVEELQDRV LILERQGHDK
   301  DLQLHQSQLE LQEVRLSCRQ LQVKVEELTE ERSLQSSAAT STSLLSEIEQ SMEAEELEQE
   361  REQLRLQLWE AYCQVRYLCS HLRGNDSADS AVSTDSSMDE SSETSSAKDV PAGSLRTALN
   421  ELKRLIQSIV DGMEPTVTLL SVEMTALKEE RDRLRVTSED KEPKEQLQKA IRDRDEAIAK
   481  KNAVELELAK CRMDMMSLNS QLLDAIQQKL NLSQQLEAWQ DDMHRVIDRQ LMDTHLKERS
   541  QPAAALCRGH SAGRGDEPSI AEGKRLFSFF RKI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BICDL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.53
Highest tissue expression
113 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 113 nTPM
  • pituitary gland: 64 nTPM
  • skin: 50 nTPM
  • retina: 40 nTPM
  • cerebellum: 32 nTPM
  • esophagus: 29 nTPM

Single-cell type

  • loop of henle epithelial cells: 564 nCPM
  • cone photoreceptor cells: 544 nCPM
  • rod photoreceptor cells: 532 nCPM
  • somatotrophs: 468 nCPM
  • proximal tubule cells: 404 nCPM
  • distal convoluted tubule cells: 400 nCPM

Immune cell

  • memory CD4 T-cell: 1.1 nTPM
  • gdT-cell: 1 nTPM
  • memory CD8 T-cell: 0.9 nTPM
  • naive CD4 T-cell: 0.8 nTPM
  • naive CD8 T-cell: 0.7 nTPM
  • MAIT T-cell: 0.4 nTPM

Brain region

  • cerebral cortex: 31 nTPM
  • hypothalamus: 28 nTPM
  • hippocampal formation: 22 nTPM
  • amygdala: 22 nTPM
  • basal ganglia: 21 nTPM
  • thalamus: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.34
gnomAD pLI
0.95
DepMap mean gene effect
-0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BICDL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BICDL1 as an antibody target. Whether an autoantibody or antibody against BICDL1 could matter depends on whether native BICDL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BICDL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BICDL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BICDL1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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