Seroatlas · Human Serome Atlas

C15orf39

Uncharacterized protein C15orf39

Also known as: CO039_HUMAN, DKFZP434H132, FLJ46337

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZRI6
Gene: C15orf39
Ensembl: ENSG00000167173
Chromosome: 15
Canonical length: 1047 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1047 residues, UniProt reviewed canonical sequence.

>Q6ZRI6|C15orf39
     1  MAEKRPLRTL GPVMYGKLPR LETDSGLEHS LPHSVGNQDP CTYKGSYFSC PMAGTPKAES
    61  EQLASWTPYP PLYSTGMAGP PLQADNLLTN CLFYRSPAEG PEKMQDSSPV ELLPFSPQAH
   121  SYPGPPLAAP KPVYRNPLCY GLSTCLGEGA VKRPLDVDWT LATGPLLPSA DPPCSLAPAP
   181  SKGQTLDGTF LRGVPAEGSS KDSSGSFSPC QPFLEKYQTI HSTGFLASRY TGPYPRNSKQ
   241  AMSEGPSSPW TQLAQPLGPP CQDTGPTHYP PPHHPPPHPP QALPCPPACR HPEKQGSYSP
   301  ALPLQPLGGH KGTGYQAGGL GSPYLRQQAA QAPYIPPLGL DAYPYPSAPL PAPSPGLKLE
   361  PPLTPRCPLD FAPQTLSFPY ARDDLSLYGA SPGLGGTPPS QNNVRAVPQP GAFQRACQPL
   421  PASQPCSEPV RPAQEAEEKT WLPSCRKEKL QPRLSEHSGP PIVIRDSPVP CTPPALPPCA
   481  RECQSLPQKE GARPPSSPPM PVIDNVFSLA PYRDYLDVPA PEATTEPDSA TAEPDSAPAT
   541  SEGQDKGCRG TLPAQEGPSG SKPLRGSLKE EVALDLSVRK PTAEASPVKA SRSVEHAKPT
   601  AAMDVPDVGN MVSDLPGLKK IDTEAPGLPG VPVTTDAMPR TNFHSSVAFM FRKFKILRPA
   661  PLPAAVVPST PTSAPAPTQP APTPTSGPIG LRILAQQPLS VTCFSLALPS PPAVAVASPA
   721  PAPAPSPAPA RAQAPASARD PAPAPAPVAG PAPASTSAPG DSLEQHFTGL HASLCDAISG
   781  SVAHSPPEKL REWLETAGPW GQAAWQDCQG VQGLLAKLLS QLQRFDRTHR CPFPHVVRAG
   841  AIFVPIHLVK ERLFPRLPPA SVDHVLQEHR VELRPTTLSE ERALRELALP GCTSRMLKLL
   901  ALRQLPDIYP DLLGLQWRDC VRRQLGDFDT EAGAVSSSEP TVARGEPESL ALAQKSPAPK
   961  VRKPGRKPPT PGPEKAEAAA GEESCGASPT PATSASPPGP TLKARFRSLL ETAWLNGLAL
  1021  PTWGHKSSRP DQPSPCPQLL DSQSHHL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C15orf39 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 69 nTPM

Expression across tissuesHPA

Tissue

testis: 69 nTPM
bone marrow: 58 nTPM
blood vessel: 28 nTPM
spleen: 24 nTPM
esophagus: 20 nTPM
ovary: 17 nTPM

Single-cell type

late spermatids: 145 nCPM
neutrophils: 119 nCPM
late primary spermatocytes: 88 nCPM
early spermatids: 54 nCPM
esophageal apical cells: 50 nCPM
monocytes: 46 nCPM

Immune cell

neutrophil: 24 nTPM
eosinophil: 19 nTPM
non-classical monocyte: 16 nTPM
intermediate monocyte: 12 nTPM
basophil: 8.6 nTPM
plasmacytoid DC: 8.1 nTPM

Brain region

cerebral cortex: 26 nTPM
hypothalamus: 24 nTPM
medulla oblongata: 22 nTPM
midbrain: 20 nTPM
spinal cord: 19 nTPM
choroid plexus: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.57
gnomAD pLI: 0.01
gnomAD missense Z: 1.12
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Family of unknown function DUF5525
Family of unknown function (DUF5525)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of C15orf39 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PRMT2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C15orf39 as an antibody target. Whether an autoantibody or antibody against C15orf39 could matter depends on whether native C15orf39 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C15orf39 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C15orf39 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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