Seroatlas · Human Serome Atlas

RGS19

Regulator of G-protein signaling 19

Also known as: GAIP, RGS19_HUMAN, RGSGAIP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P49795
Gene: RGS19
Ensembl: ENSG00000171700
Chromosome: 20
Canonical length: 217 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli fibrillar center,Cell Junctions

OverviewNCBI Gene

G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

217 residues, UniProt reviewed canonical sequence.

>P49795|RGS19
     1  MPTPHEAEKQ ITGPEEADRP PSMSSHDTAS PAAPSRNPCC LCWCCCCSCS WNQERRRAWQ
    61  ASRESKLQPL PSCEVCATPS PEEVQSWAQS FDKLMHSPAG RSVFRAFLRT EYSEENMLFW
   121  LACEELKAEA NQHVVDEKAR LIYEDYVSIL SPKEVSLDSR VREGINKKMQ EPSAHTFDDA
   181  QLQIYTLMHR DSYPRFLSSP TYRALLLQGP SQSSSEA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RGS19 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 74 nTPM

Expression across tissuesHPA

Tissue

spleen: 74 nTPM
bone marrow: 54 nTPM
lymph node: 33 nTPM
appendix: 27 nTPM
small intestine: 20 nTPM
lung: 19 nTPM

Single-cell type

neutrophils: 274 nCPM
hofbauer cells: 161 nCPM
neutrophil progenitors: 129 nCPM
kupffer cells: 123 nCPM
megakaryocytes: 111 nCPM
monocytes: 110 nCPM

Immune cell

eosinophil: 763 nTPM
neutrophil: 609 nTPM
non-classical monocyte: 460 nTPM
intermediate monocyte: 396 nTPM
basophil: 291 nTPM
classical monocyte: 274 nTPM

Brain region

medulla oblongata: 23 nTPM
white matter: 22 nTPM
thalamus: 22 nTPM
spinal cord: 21 nTPM
pons: 18 nTPM
cerebral cortex: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.3
gnomAD pLI: 0.96
gnomAD missense Z: 1.06
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

GTPase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RGS19 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RGS19 as an antibody target. Whether an autoantibody or antibody against RGS19 could matter depends on whether native RGS19 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RGS19 is annotated at the cell surface, where native RGS19 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RGS19 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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