ERH
Enhancer of rudimentary homolog
Also known as: DROER, ERH_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P84090
- Gene
- ERH
- Ensembl
- ENSG00000100632
- Chromosome
- 14
- Canonical length
- 104 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Cytosol
- Quaternary structure
- Homodimer
OverviewNCBI Gene
Enables methyl-CpG binding activity. Predicted to be involved in pyrimidine nucleoside metabolic process. Located in midbody and nucleus. Part of methylosome. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
104 residues, UniProt reviewed canonical sequence.
>P84090|ERH
1 MSHTILLVQP TKRPEGRTYA DYESVNECME GVCKMYEEHL KRMNPNSPSI TYDISQLFDF
61 IDDLADLSCL VYRADTQTYQ PYNKDWIKEK IYVLLRRQAQ QAGKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ERH can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.35
- Highest tissue expression
- 198 nTPM
Expression across tissuesHPA
Tissue
- thymus: 198 nTPM
- tonsil: 158 nTPM
- ovary: 145 nTPM
- epididymis: 142 nTPM
- lymph node: 137 nTPM
- bone marrow: 136 nTPM
Single-cell type
- oocytes: 824 nCPM
- extravillous trophoblasts: 649 nCPM
- migrating cytotrophoblasts: 607 nCPM
- gastric progenitor cells: 526 nCPM
- cytotrophoblasts: 521 nCPM
- decidual stromal cells: 453 nCPM
Immune cell
- total PBMC: 147 nTPM
- plasmacytoid DC: 123 nTPM
- memory B-cell: 123 nTPM
- NK-cell: 122 nTPM
- T-reg: 117 nTPM
- myeloid DC: 108 nTPM
Brain region
- hypothalamus: 110 nTPM
- white matter: 101 nTPM
- spinal cord: 99 nTPM
- medulla oblongata: 88 nTPM
- midbrain: 86 nTPM
- choroid plexus: 85 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about ERH.
Disease | ImmuneIEDB
Conditions an epitope on ERH was assayed in.
- melanoma T cell
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.42
- gnomAD pLI
- 0.89
- gnomAD missense Z
- 2.33
- DepMap mean gene effect
- -2.07
- DepMap dependency class
- pan
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Enhancer of rudimentary
- Enhancer of rudimentary superfamily
- Enhancer of rudimentary
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of ERH in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ERH as an antibody target. Whether an autoantibody or antibody against ERH could matter depends on whether native ERH is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ERH is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ERH as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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