Seroatlas · Human Serome Atlas

ZC3H11A

Zinc finger CCCH domain-containing protein 11A

Also known as: KIAA0663, ZC11A_HUMAN, ZC3HDC11A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75152
Gene: ZC3H11A
Ensembl: ENSG00000058673
Chromosome: 1
Canonical length: 810 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles

OverviewNCBI Gene

Enables RNA binding activity. Involved in poly(A)+ mRNA export from nucleus. Located in transcription export complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

810 residues, UniProt reviewed canonical sequence.

>O75152|ZC3H11A
     1  MPNQGEDCYF FFYSTCTKGD SCPFRHCEAA IGNETVCTLW QEGRCFRQVC RFRHMEIDKK
    61  RSEIPCYWEN QPTGCQKLNC AFHHNRGRYV DGLFLPPSKT VLPTVPESPE EEVKASQLSV
   121  QQNKLSVQSN PSPQLRSVMK VESSENVPSP THPPVVINAA DDDEDDDDQF SEEGDETKTP
   181  TLQPTPEVHN GLRVTSVRKP AVNIKQGECL NFGIKTLEEI KSKKMKEKSK KQGEGSSGVS
   241  SLLLHPEPVP GPEKENVRTV VRTVTLSTKQ GEEPLVRLSL TERLGKRKFS AGGDSDPPLK
   301  RSLAQRLGKK VEAPETNIDK TPKKAQVSKS LKERLGMSAD PDNEDATDKV NKVGEIHVKT
   361  LEEILLERAS QKRGELQTKL KTEGPSKTDD STSGARSSST IRIKTFSEVL AEKKHRQQEA
   421  ERQKSKKDTT CIKLKIDSEI KKTVVLPPIV ASRGQSEEPA GKTKSMQEVH IKTLEEIKLE
   481  KALRVQQSSE SSTSSPSQHE ATPGARRLLR ITKRTGMKEE KNLQEGNEVD SQSSIRTEAK
   541  EASGETTGVD ITKIQVKRCE TMREKHMQKQ QEREKSVLTP LRGDVASCNT QVAEKPVLTA
   601  VPGITRHLTK RLPTKSSQKV EVETSGIGDS LLNVKCAAQT LEKRGKAKPK VNVKPSVVKV
   661  VSSPKLAPKR KAVEMHAAVI AAVKPLSSSS VLQEPPAKKA AVAVVPLVSE DKSVTVPEAE
   721  NPRDSLVLPP TQSSSDSSPP EVSGPSSSQM SMKTRRLSSA STGKPPLSVE DDFEKLIWEI
   781  SGGKLEAEID LDPGKDEDDL LLELSEMIDS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZC3H11A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

thymus: 28 nTPM
bone marrow: 26 nTPM
lymph node: 23 nTPM
skin: 23 nTPM
tonsil: 22 nTPM
skeletal muscle: 21 nTPM

Single-cell type

oligodendrocytes: 179 nCPM
choroid plexus epithelial cells: 164 nCPM
bergmann glia: 141 nCPM
astrocytes: 137 nCPM
oligodendrocyte progenitor cells: 127 nCPM
microglia: 102 nCPM

Immune cell

basophil: 16 nTPM
neutrophil: 7.4 nTPM
MAIT T-cell: 7.2 nTPM
non-classical monocyte: 5.8 nTPM
naive CD4 T-cell: 5.7 nTPM
eosinophil: 5.2 nTPM

Brain region

white matter: 42 nTPM
choroid plexus: 38 nTPM
basal ganglia: 37 nTPM
cerebral cortex: 37 nTPM
cerebellum: 35 nTPM
pons: 33 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.19
gnomAD pLI: 1
gnomAD missense Z: 1.69
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

poly(A)+ mRNA export from nucleus

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZC3H11A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZC3H11A as an antibody target. Whether an autoantibody or antibody against ZC3H11A could matter depends on whether native ZC3H11A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZC3H11A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZC3H11A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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