Seroatlas · Human Serome Atlas

POLD2

DNA polymerase delta subunit 2

Also known as: DPOD2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P49005
Gene: POLD2
Ensembl: ENSG00000106628
Chromosome: 7
Canonical length: 469 aa
Protein class: Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes the 50-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein is required for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclear antigen (PCNA). Expression of this gene may be a marker for ovarian carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Mar 2012]

Canonical amino-acid sequenceUniProt

469 residues, UniProt reviewed canonical sequence.

>P49005|POLD2
     1  MFSEQAAQRA HTLLSPPSAN NATFARVPVA TYTNSSQPFR LGERSFSRQY AHIYATRLIQ
    61  MRPFLENRAQ QHWGSGVGVK KLCELQPEEK CCVVGTLFKA MPLQPSILRE VSEEHNLLPQ
   121  PPRSKYIHPD DELVLEDELQ RIKLKGTIDV SKLVTGTVLA VFGSVRDDGK FLVEDYCFAD
   181  LAPQKPAPPL DTDRFVLLVS GLGLGGGGGE SLLGTQLLVD VVTGQLGDEG EQCSAAHVSR
   241  VILAGNLLSH STQSRDSINK AKYLTKKTQA ASVEAVKMLD EILLQLSASV PVDVMPGEFD
   301  PTNYTLPQQP LHPCMFPLAT AYSTLQLVTN PYQATIDGVR FLGTSGQNVS DIFRYSSMED
   361  HLEILEWTLR VRHISPTAPD TLGCYPFYKT DPFIFPECPH VYFCGNTPSF GSKIIRGPED
   421  QTVLLVTVPD FSATQTACLV NLRSLACQPI SFSGFGAEDD DLGGLGLGP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against POLD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 114 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 114 nTPM
liver: 110 nTPM
esophagus: 84 nTPM
choroid plexus: 83 nTPM
heart muscle: 82 nTPM
pancreas: 71 nTPM

Single-cell type

late spermatids: 496 nCPM
esophageal basal cells: 240 nCPM
esophageal suprabasal cells: 208 nCPM
oocytes: 157 nCPM
decidual stromal cells: 135 nCPM
fallopian tube ciliated cells: 134 nCPM

Immune cell

plasmacytoid DC: 99 nTPM
memory B-cell: 72 nTPM
naive CD4 T-cell: 72 nTPM
naive B-cell: 71 nTPM
MAIT T-cell: 67 nTPM
myeloid DC: 60 nTPM

Brain region

thalamus: 60 nTPM
choroid plexus: 48 nTPM
medulla oblongata: 42 nTPM
amygdala: 42 nTPM
midbrain: 42 nTPM
pons: 41 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.69
gnomAD pLI: 0
gnomAD missense Z: 1.65
DepMap mean gene effect: -1.15
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

DNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

DNA polymerase alpha/delta/epsilon, subunit B
DNA polymerase alpha/epsilon subunit B
DNA polymerase delta/II small subunit family
DNA polymerase delta subunit, OB-fold domain
DNA polymerase delta subunit 2, C-terminal domain
DNA polymerase delta subunit OB-fold domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of POLD2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads POLD2 as an antibody target. Whether an autoantibody or antibody against POLD2 could matter depends on whether native POLD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

POLD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label POLD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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