Seroatlas · Human Serome Atlas

FAM168A

Protein FAM168A

Also known as: F168A_HUMAN, KIAA0280, TCRP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q92567
Gene: FAM168A
Ensembl: ENSG00000054965
Chromosome: 11
Canonical length: 244 aa
Protein class: Disease related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Involved in positive regulation of base-excision repair. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

244 residues, UniProt reviewed canonical sequence.

>Q92567|FAM168A
     1  MNPVYSPVQP GAPYGNPKNM AYTGYPTAYP AAAPAYNPSL YPTNSPSYAP EFQFLHSAYA
    61  TLLMKQAWPQ NSSSCGTEGT FHLPVDTGTE NRTYQASSAA FRYTAGTPYK VPPTQSNTAP
   121  PPYSPSPNPY QTAMYPIRSA YPQQNLYAQG AYYTQPVYAA QPHVIHHTTV VQPNSIPSAI
   181  YPAPVAAPRT NGVAMGMVAG TTMAMSAGTL LTTPQHTAIG AHPVSMPTYR AQGTPAYSYV
   241  PPHW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM168A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.71
Highest tissue expression: 57 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 57 nTPM
spinal cord: 49 nTPM
retina: 46 nTPM
amygdala: 43 nTPM
midbrain: 41 nTPM
hippocampal formation: 40 nTPM

Single-cell type

neutrophil progenitors: 335 nCPM
cone photoreceptor cells: 325 nCPM
microglia: 290 nCPM
myonuclei: 270 nCPM
rod photoreceptor cells: 263 nCPM
retinal ganglion cells: 259 nCPM

Immune cell

basophil: 6 nTPM
neutrophil: 2.9 nTPM
intermediate monocyte: 2.3 nTPM
non-classical monocyte: 1.5 nTPM
plasmacytoid DC: 1.4 nTPM
classical monocyte: 1.3 nTPM

Brain region

medulla oblongata: 149 nTPM
thalamus: 141 nTPM
pons: 137 nTPM
spinal cord: 131 nTPM
hypothalamus: 130 nTPM
midbrain: 129 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.23
gnomAD pLI: 0.99
gnomAD missense Z: 1.66
DepMap mean gene effect: -0.27
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

positive regulation of base-excision repair

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FAM168A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM168A as an antibody target. Whether an autoantibody or antibody against FAM168A could matter depends on whether native FAM168A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM168A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM168A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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