DNA polymerase lambda lyase domain superfamily

Definition

DNA polymerase lambda is a repair polymerase that has both DNA polymerase and terminal transferase activities. It has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity [[cite:PMID:11457865], [cite:PMID:15537631]]. Structural modeling suggests that pol lambda contains the palm, fingers, thumb, and lyase domains present in pol beta, as well as an additional N-terminal BRCT domain and a serine-proline-rich linker that are presumably involved in protein-protein interactions PMID:12911298. This superfamily represents the lyase domain of pol lambda which is also known as the 8kDa domain [[cite:PMID:22306405], [cite:PMID:11823435]].

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• DNTT
• MUS81
• POLB
• POLL
• POLM