Seroatlas · Human Serome Atlas

OXSR1

Serine/threonine-protein kinase OSR1

Also known as: KIAA1101, OSR1, OXSR1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95747
Gene
OXSR1
Ensembl
ENSG00000172939
Chromosome
3
Canonical length
527 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

527 residues, UniProt reviewed canonical sequence.

>O95747|OXSR1
     1  MSEDSSALPW SINRDDYELQ EVIGSGATAV VQAAYCAPKK EKVAIKRINL EKCQTSMDEL
    61  LKEIQAMSQC HHPNIVSYYT SFVVKDELWL VMKLLSGGSV LDIIKHIVAK GEHKSGVLDE
   121  STIATILREV LEGLEYLHKN GQIHRDVKAG NILLGEDGSV QIADFGVSAF LATGGDITRN
   181  KVRKTFVGTP CWMAPEVMEQ VRGYDFKADI WSFGITAIEL ATGAAPYHKY PPMKVLMLTL
   241  QNDPPSLETG VQDKEMLKKY GKSFRKMISL CLQKDPEKRP TAAELLRHKF FQKAKNKEFL
   301  QEKTLQRAPT ISERAKKVRR VPGSSGRLHK TEDGGWEWSD DEFDEESEEG KAAISQLRSP
   361  RVKESISNSE LFPTTDPVGT LLQVPEQISA HLPQPAGQIA TQPTQVSLPP TAEPAKTAQA
   421  LSSGSGSQET KIPISLVLRL RNSKKELNDI RFEFTPGRDT AEGVSQELIS AGLVDGRDLV
   481  IVAANLQKIV EEPQSNRSVT FKLASGVEGS DIPDDGKLIG FAQLSIS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OXSR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
35 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 35 nTPM
  • esophagus: 33 nTPM
  • tongue: 33 nTPM
  • bone marrow: 32 nTPM
  • urinary bladder: 25 nTPM
  • parathyroid gland: 25 nTPM

Single-cell type

  • neutrophils: 1,660 nCPM
  • monocytes: 613 nCPM
  • urothelial cells: 522 nCPM
  • esophageal apical cells: 510 nCPM
  • ocular epithelial cells: 431 nCPM
  • endometrial glandular cells: 353 nCPM

Immune cell

  • basophil: 6.9 nTPM
  • eosinophil: 3.9 nTPM
  • neutrophil: 3.2 nTPM
  • NK-cell: 3.1 nTPM
  • T-reg: 2.9 nTPM
  • intermediate monocyte: 2.8 nTPM

Brain region

  • cerebellum: 25 nTPM
  • choroid plexus: 24 nTPM
  • cerebral cortex: 24 nTPM
  • thalamus: 21 nTPM
  • medulla oblongata: 20 nTPM
  • midbrain: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.37
gnomAD pLI
0.77
gnomAD missense Z
2.6
DepMap mean gene effect
-0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of OXSR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OXSR1 as an antibody target. Whether an autoantibody or antibody against OXSR1 could matter depends on whether native OXSR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OXSR1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label OXSR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/OXSR1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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