Seroatlas · Human Serome Atlas

RELT

Tumor necrosis factor receptor superfamily member 19L

Also known as: FLJ14993, TNFRSF19L, TR19L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q969Z4
Gene
RELT
Ensembl
ENSG00000054967
Chromosome
11
Canonical length
430 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Nucleoli,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is especially abundant in hematologic tissues. It has been shown to activate the NF-kappaB pathway and selectively bind TNF receptor-associated factor 1 (TRAF1). This receptor is capable of stimulating T-cell proliferation in the presence of CD3 signaling, which suggests its regulatory role in immune response. Two alternatively spliced transcript variants of this gene encoding the same protein have been reported. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

430 residues, UniProt reviewed canonical sequence.

>Q969Z4|RELT
     1  MKPSLLCRPL SCFLMLLPWP LATLTSTTLW QCPPGEEPDL DPGQGTLCRP CPPGTFSAAW
    61  GSSPCQPHAR CSLWRRLEAQ VGMATRDTLC GDCWPGWFGP WGVPRVPCQP CSWAPLGTHG
   121  CDEWGRRARR GVEVAAGASS GGETRQPGNG TRAGGPEETA AQYAVIAIVP VFCLMGLLGI
   181  LVCNLLKRKG YHCTAHKEVG PGPGGGGSGI NPAYRTEDAN EDTIGVLVRL ITEKKENAAA
   241  LEELLKEYHS KQLVQTSHRP VSKLPPAPPN VPHICPHRHH LHTVQGLASL SGPCCSRCSQ
   301  KKWPEVLLSP EAVAATTPVP SLLPNPTRVP KAGAKAGRQG EITILSVGRF RVARIPEQRT
   361  SSMVSEVKTI TEAGPSWGDL PDSPQPGLPP EQQALLGSGG SRTKWLKPPA ENKAEENRYV
   421  VRLSESNLVI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RELT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.59
Highest tissue expression
146 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 146 nTPM
  • skeletal muscle: 23 nTPM
  • spleen: 20 nTPM
  • appendix: 12 nTPM
  • lymph node: 11 nTPM
  • lung: 11 nTPM

Single-cell type

  • neutrophils: 145 nCPM
  • pdcs: 89 nCPM
  • monocytes: 86 nCPM
  • cdc: 69 nCPM
  • macrophages: 47 nCPM
  • monocyte progenitors: 46 nCPM

Immune cell

  • non-classical monocyte: 35 nTPM
  • intermediate monocyte: 25 nTPM
  • eosinophil: 22 nTPM
  • neutrophil: 20 nTPM
  • classical monocyte: 13 nTPM
  • myeloid DC: 12 nTPM

Brain region

  • white matter: 32 nTPM
  • medulla oblongata: 26 nTPM
  • pons: 24 nTPM
  • cerebral cortex: 23 nTPM
  • spinal cord: 22 nTPM
  • hypothalamus: 21 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RELT.

Disease | AllUniProt

Conditions RELT is implicated in, by any mechanism.

Disease | GeneticClinVar

8 pathogenic / likely-pathogenic of 104 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.93
gnomAD pLI
0
gnomAD missense Z
-0.27
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RELT in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RELT as an antibody target. Whether an autoantibody or antibody against RELT could matter depends on whether native RELT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RELT is annotated at the cell surface, where native RELT is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RELT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RELT. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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