Seroatlas · Human Serome Atlas

RELL2

RELT-like protein 2

Also known as: C5orf16, FLJ90583, RELL2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NC24
Gene: RELL2
Ensembl: ENSG00000164620
Chromosome: 5
Canonical length: 303 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to enable collagen binding activity. Involved in positive regulation of p38MAPK cascade. Predicted to be located in basement membrane and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

303 residues, UniProt reviewed canonical sequence.

>Q8NC24|RELL2
     1  MSEPQPDLEP PQHGLYMLFL LVLVFFLMGL VGFMICHVLK KKGYRCRTSR GSEPDDAQLQ
    61  PPEDDDMNED TVERIVRCII QNEANAEALK EMLGDSEGEG TVQLSSVDAT SSLQDGAPSH
   121  HHTVHLGSAA PCLHCSRSKR PPLVRQGRSK EGKSRPRTGE TTVFSVGRFR VTHIEKRYGL
   181  HEHRDGSPTD RSWGSGGGQD PGGGQGSGGG QPKAGMPAME RLPPERPQPQ VLASPPVQNG
   241  GLRDSSLTPR ALEGNPRASA EPTLRAGGRG PSPGLPTQEA NGQPSKPDTS DHQVSLPQGA
   301  GSM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RELL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 35 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 35 nTPM
midbrain: 23 nTPM
hypothalamus: 21 nTPM
cerebellum: 19 nTPM
basal ganglia: 18 nTPM
pituitary gland: 16 nTPM

Single-cell type

tuft cells: 35 nCPM
retinal horizontal cells: 32 nCPM
other brain neurons: 28 nCPM
brain inhibitory neurons: 26 nCPM
retinal amacrine cells: 26 nCPM
brain excitatory neurons: 23 nCPM

Immune cell

plasmacytoid DC: 4.6 nTPM
T-reg: 3.3 nTPM
intermediate monocyte: 2 nTPM
gdT-cell: 1.7 nTPM
memory CD4 T-cell: 1.7 nTPM
memory CD8 T-cell: 1.6 nTPM

Brain region

cerebral cortex: 75 nTPM
pons: 66 nTPM
thalamus: 55 nTPM
medulla oblongata: 47 nTPM
hypothalamus: 35 nTPM
midbrain: 35 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.71
gnomAD pLI: 0.08
gnomAD missense Z: 0.26
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

collagen binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

TNF receptor family, RELT
Tumour necrosis factor receptor superfamily member 19
RELT-like protein 2

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RELL2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RELL2 as an antibody target. Whether an autoantibody or antibody against RELL2 could matter depends on whether native RELL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RELL2 is annotated at the cell surface, where native RELL2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RELL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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