Seroatlas · Human Serome Atlas

ASIC1

Acid-sensing ion channel 1

Also known as: ACCN2, ASIC1_HUMAN, BNaC2, hBNaC2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P78348
Gene
ASIC1
Ensembl
ENSG00000110881
Chromosome
12
Canonical length
528 aa
Protein class
Predicted membrane proteins
Subcellular location
Golgi apparatus,Plasma membrane

OverviewNCBI Gene

This gene encodes a member of the acid-sensing ion channel (ASIC) family of proteins, which are part of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Members of the ASIC family are sensitive to amiloride and function in neurotransmission. The encoded proteins function in learning, pain transduction, touch sensation, and development of memory and fear. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]

Canonical amino-acid sequenceUniProt

528 residues, UniProt reviewed canonical sequence.

>P78348|ASIC1
     1  MELKAEEEEV GGVQPVSIQA FASSSTLHGL AHIFSYERLS LKRALWALCF LGSLAVLLCV
    61  CTERVQYYFH YHHVTKLDEV AASQLTFPAV TLCNLNEFRF SQVSKNDLYH AGELLALLNN
   121  RYEIPDTQMA DEKQLEILQD KANFRSFKPK PFNMREFYDR AGHDIRDMLL SCHFRGEVCS
   181  AEDFKVVFTR YGKCYTFNSG RDGRPRLKTM KGGTGNGLEI MLDIQQDEYL PVWGETDETS
   241  FEAGIKVQIH SQDEPPFIDQ LGFGVAPGFQ TFVACQEQRL IYLPPPWGTC KAVTMDSDLD
   301  FFDSYSITAC RIDCETRYLV ENCNCRMVHM PGDAPYCTPE QYKECADPAL DFLVEKDQEY
   361  CVCEMPCNLT RYGKELSMVK IPSKASAKYL AKKFNKSEQY IGENILVLDI FFEVLNYETI
   421  EQKKAYEIAG LLGDIGGQMG LFIGASILTV LELFDYAYEV IKHKLCRRGK CQKEAKRSSA
   481  DKGVALSLDD VKRHNPCESL RGHPAGMTYA ANILPHHPAR GTFEDFTC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ASIC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
30 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 30 nTPM
  • cerebral cortex: 29 nTPM
  • basal ganglia: 24 nTPM
  • hypothalamus: 19 nTPM
  • amygdala: 18 nTPM
  • hippocampal formation: 18 nTPM

Single-cell type

  • oligodendrocyte progenitor cells: 106 nCPM
  • astrocytes: 43 nCPM
  • brain inhibitory neurons: 33 nCPM
  • oligodendrocytes: 30 nCPM
  • choroid plexus epithelial cells: 22 nCPM
  • other brain neurons: 19 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • midbrain: 53 nTPM
  • thalamus: 52 nTPM
  • basal ganglia: 47 nTPM
  • hypothalamus: 45 nTPM
  • cerebral cortex: 42 nTPM
  • amygdala: 41 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.34
gnomAD pLI
0.93
gnomAD missense Z
2.82
DepMap mean gene effect
-0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ASIC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ASIC1 as an antibody target. Whether an autoantibody or antibody against ASIC1 could matter depends on whether native ASIC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ASIC1 is annotated at the cell surface, where native ASIC1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ASIC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ASIC1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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