UNC5A

Protein identityUniProt · HPA

UniProt accession

Q6ZN44

Gene

UNC5A

Ensembl

ENSG00000113763

Chromosome

5

Canonical length

842 aa

Protein class

Predicted membrane proteins

Subcellular location

Plasma membrane,Cytosol

Quaternary structure

Homodimer

OverviewNCBI Gene

UNC5A belongs to a family of netrin-1 (MIM 601614) receptors thought to mediate the chemorepulsive effect of netrin-1 on specific axons. For more information on UNC5 proteins, see UNC5C (MIM 603610).[supplied by OMIM, Apr 2004]

Canonical amino-acid sequenceUniProt

842 residues, UniProt reviewed canonical sequence.

>Q6ZN44|UNC5A
     1  MAVRPGLWPA LLGIVLAAWL RGSGAQQSAT VANPVPGANP DLLPHFLVEP EDVYIVKNKP
    61  VLLVCKAVPA TQIFFKCNGE WVRQVDHVIE RSTDGSSGLP TMEVRINVSR QQVEKVFGLE
   121  EYWCQCVAWS SSGTTKSQKA YIRIAYLRKN FEQEPLAKEV SLEQGIVLPC RPPEGIPPAE
   181  VEWLRNEDLV DPSLDPNVYI TREHSLVVRQ ARLADTANYT CVAKNIVARR RSASAAVIVY
   241  VDGSWSPWSK WSACGLDCTH WRSRECSDPA PRNGGEECQG TDLDTRNCTS DLCVHTASGP
   301  EDVALYVGLI AVAVCLVLLL LVLILVYCRK KEGLDSDVAD SSILTSGFQP VSIKPSKADN
   361  PHLLTIQPDL STTTTTYQGS LCPRQDGPSP KFQLTNGHLL SPLGGGRHTL HHSSPTSEAE
   421  EFVSRLSTQN YFRSLPRGTS NMTYGTFNFL GGRLMIPNTG ISLLIPPDAI PRGKIYEIYL
   481  TLHKPEDVRL PLAGCQTLLS PIVSCGPPGV LLTRPVILAM DHCGEPSPDS WSLRLKKQSC
   541  EGSWEDVLHL GEEAPSHLYY CQLEASACYV FTEQLGRFAL VGEALSVAAA KRLKLLLFAP
   601  VACTSLEYNI RVYCLHDTHD ALKEVVQLEK QLGGQLIQEP RVLHFKDSYH NLRLSIHDVP
   661  SSLWKSKLLV SYQEIPFYHI WNGTQRYLHC TFTLERVSPS TSDLACKLWV WQVEGDGQSF
   721  SINFNITKDT RFAELLALES EAGVPALVGP SAFKIPFLIR QKIISSLDPP CRRGADWRTL
   781  AQKLHLDSHL SFFASKPSPT AMILNLWEAR HFPNGNLSQL AAAVAGLGQP DAGLFTVSEA
   841  EC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UNC5A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.36

Highest tissue expression

59 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.2

gnomAD pLI

1

gnomAD missense Z

2.75

DepMap mean gene effect

0.06

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• anterior/posterior axon guidance
• apoptotic process
• netrin-activated signaling pathway
• neuron projection development

Molecular functions

• netrin receptor activity

Cellular components

• membrane raft
• neuron projection membrane
• neuronal cell body membrane
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Death domain
• Thrombospondin type-1 (TSP1) repeat
• ZU5 domain
• Immunoglobulin domain subtype
• Immunoglobulin-like domain
• Death-like domain superfamily
• Immunoglobulin I-set
• Immunoglobulin-like fold
• UPA domain
• Immunoglobulin-like domain superfamily
• Thrombospondin type-1 repeat superfamily
• Netrin receptor UNC5A-D
• Netrin receptor UNC5A-D-like, N-terminal domain
• Death domain
• ZU5 domain
• Immunoglobulin I-set domain
• UPA domain
• Netrin receptor unc-5 N-terminal domain
• UNC5A, death domain

KeywordsUniProt

• Apoptosis
• Cell membrane
• Cell projection
• Developmental protein
• Disulfide bond
• Glycoprotein
• Immunoglobulin domain
• Membrane
• Phosphoprotein
• Receptor
• Signal
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of UNC5A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• MAGED1
• PRKCABP
• PICK1