Seroatlas · Human Serome Atlas

CEP89

Centrosomal protein of 89 kDa

Also known as: CCDC123, CEP89_HUMAN, FLJ14640

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96ST8
Gene
CEP89
Ensembl
ENSG00000121289
Chromosome
19
Canonical length
783 aa
Protein class
Disease related genes, Predicted intracellular proteins
Subcellular location
Primary cilium,Centrosome,Basal body,Cytosol

OverviewNCBI Gene

Involved in mitochondrial cytochrome c oxidase assembly and non-motile cilium assembly. Acts upstream of or within cilium assembly. Located in several cellular components, including microtubule cytoskeleton; mitochondrial intermembrane space; and nuclear body. Part of ciliary transition fiber. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

783 residues, UniProt reviewed canonical sequence.

>Q96ST8|CEP89
     1  MLLGFRRGRR SHFKHIIHGL LPAASVAPKA AVPRTPPPRS PNPSPERPRS ALAAAILATT
    61  LTGRTVAIPQ PRQRSRSESD VSSVEQDSFI EPYATTSQLR PRPNWQSEMG RRSSLPSFET
   121  LDYGDEEDIE TQLSSSGKEL GDVSAREDRG GHSDDLYAVP HRNQVPLLHE VNSEDDENIS
   181  HQDGFPGSPP APQRTQQKDG KHPVLNLKDE KPPLCEKPPP SPDITGRARQ RYTEITREKF
   241  EALKEENMDL NNMNQSLTLE LNTMKQAMKE LQLKLKGMEK EKRKLKEAEK ASSQEVAAPE
   301  LLYLRKQAQE LVDENDGLKM TVHRLNVELS RYQTKFRHLS KEESLNIEGL PSKGPIPPWL
   361  LDIKYLSPLL LAYEDMMKEK DELNATLKEE MRMFRMRVQE VVKENEELHQ ELNKSSAVTS
   421  EEWRQLQTQA KLVLEENKLL LEQLEIQQRK AKDSHQERLQ EVSKLTKQLM LLEAKTHGQE
   481  KELAENREQL EILRAKCQEL KTHSDGKIAV EVHKSIVNEL KSQLQKEEEK ERAEMEELME
   541  KLTVLQAQKK SLLLEKNSLT EQNKALEAEL ERAQKINRKS QKKIEVLKKQ VEKAMGNEMS
   601  AHQYLANLVG LAENITQERD SLMCLAKCLE SEKDGVLNKV IKSNIRLGKL EEKVKGYKKQ
   661  AALKLGDISH RLLEQQEDFA GKTAQYRQEM RHLHQVLKDK QEVLDQALQQ NREMEGELEV
   721  IWESTFRENR RIRELLQDTL TRTGVQDNPR ALVAPSLNGV SQADLLDGCD VCSYDLKSHA
   781  PTC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CEP89 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
12 nTPM

Expression across tissuesHPA

Tissue

  • prostate: 12 nTPM
  • endometrium: 9.8 nTPM
  • ovary: 9.6 nTPM
  • fallopian tube: 9.4 nTPM
  • cervix: 9.2 nTPM
  • choroid plexus: 9 nTPM

Single-cell type

  • ependymal cells: 95 nCPM
  • respiratory ciliated cells: 94 nCPM
  • fibro-adipogenic progenitors: 88 nCPM
  • endometrial ciliated cells: 87 nCPM
  • prostatic glandular cells: 71 nCPM
  • endometrial luminal cells: 68 nCPM

Immune cell

  • basophil: 13 nTPM
  • naive B-cell: 5.7 nTPM
  • MAIT T-cell: 4.9 nTPM
  • intermediate monocyte: 4.6 nTPM
  • plasmacytoid DC: 3.7 nTPM
  • neutrophil: 3.6 nTPM

Brain region

  • choroid plexus: 22 nTPM
  • cerebellum: 21 nTPM
  • hypothalamus: 21 nTPM
  • hippocampal formation: 20 nTPM
  • cerebral cortex: 19 nTPM
  • amygdala: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.22
gnomAD pLI
0
gnomAD missense Z
0.47
DepMap mean gene effect
-0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Centrosomal protein of 89kDa

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CEP89 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CEP89 as an antibody target. Whether an autoantibody or antibody against CEP89 could matter depends on whether native CEP89 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CEP89 is annotated at the cell surface, where native CEP89 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CEP89 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CEP89. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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