Seroatlas · Human Serome Atlas

ASIC2

Acid-sensing ion channel 2

Also known as: ACCN, ACCN1, ASIC2_HUMAN, ASIC2a, BNaC1, BNC1, hBNaC1, MDEG

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q16515
Gene
ASIC2
Ensembl
ENSG00000108684
Chromosome
17
Canonical length
512 aa
Protein class
Plasma proteins, Predicted membrane proteins
Quaternary structure
Homotrimer

OverviewNCBI Gene

This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 3 has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Feb 2012]

Canonical amino-acid sequenceUniProt

512 residues, UniProt reviewed canonical sequence.

>Q16515|ASIC2
     1  MDLKESPSEG SLQPSSIQIF ANTSTLHGIR HIFVYGPLTI RRVLWAVAFV GSLGLLLVES
    61  SERVSYYFSY QHVTKVDEVV AQSLVFPAVT LCNLNGFRFS RLTTNDLYHA GELLALLDVN
   121  LQIPDPHLAD PSVLEALRQK ANFKHYKPKQ FSMLEFLHRV GHDLKDMMLY CKFKGQECGH
   181  QDFTTVFTKY GKCYMFNSGE DGKPLLTTVK GGTGNGLEIM LDIQQDEYLP IWGETEETTF
   241  EAGVKVQIHS QSEPPFIQEL GFGVAPGFQT FVATQEQRLT YLPPPWGECR SSEMGLDFFP
   301  VYSITACRID CETRYIVENC NCRMVHMPGD APFCTPEQHK ECAEPALGLL AEKDSNYCLC
   361  RTPCNLTRYN KELSMVKIPS KTSAKYLEKK FNKSEKYISE NILVLDIFFE ALNYETIEQK
   421  KAYEVAALLG DIGGQMGLFI GASILTILEL FDYIYELIKE KLLDLLGKEE DEGSHDENVS
   481  TCDTMPNHSE TISHTVNVPL QTTLGTLEEI AC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ASIC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 13 nTPM
  • hypothalamus: 10 nTPM
  • amygdala: 8.6 nTPM
  • cerebellum: 8.6 nTPM
  • hippocampal formation: 7.7 nTPM
  • basal ganglia: 6 nTPM

Single-cell type

  • respiratory ionocytes: 312 nCPM
  • oligodendrocyte progenitor cells: 290 nCPM
  • retinal bipolar cells: 283 nCPM
  • retinal amacrine cells: 208 nCPM
  • late spermatids: 192 nCPM
  • other brain neurons: 137 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • basal ganglia: 31 nTPM
  • cerebral cortex: 29 nTPM
  • white matter: 20 nTPM
  • hippocampal formation: 17 nTPM
  • medulla oblongata: 17 nTPM
  • midbrain: 16 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ASIC2.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 91 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.19
gnomAD pLI
1
gnomAD missense Z
1.67
DepMap mean gene effect
-0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ASIC2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ASIC2 as an antibody target. Whether an autoantibody or antibody against ASIC2 could matter depends on whether native ASIC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ASIC2 is annotated at the cell surface, where native ASIC2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ASIC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ASIC2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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